The burden of Alzheimer's disease mortality in the United States, 1999-2018
Authors/Creators
Xuan Zhao
Cancan Li
Guoyong Ding
Yuanyuan Heng
An Li
Wei Wang, Edith Cowan UniversityFollow
Haifeng Hou
Jun Wen, Edith Cowan UniversityFollow
Yanbo Zhang
Abstract
Background: The increasing prevalence of Alzheimer's disease (AD), along with the associated burden on healthcare systems, presents a substantial public health challenge. Objective: This study aimed to investigate trends in AD mortality and the relevant burden across the United States (U.S.) from 1999 to 2018 and to predict mortality trends between 2019 and 2023. Methods: Data on AD-related deaths between 1999 and 2018 were collected from the WONDER database administered by the U.S. Centers for Disease Control and Prevention (CDC). The Joinpoint Regression Program was used to analyze mortality trends due to AD. Years of life lost (YLL) were calculated to explore the burden of AD deaths. An autoregressive integrated moving average (ARIMA) model was employed to forecast mortality trends from 2019 to 2023. Results: Over a recent 20-year period, the number of AD deaths in the U.S. increased from 44,536 (31,145 females and 13,391 males) to 122,019 (84,062 females and 37,957 males). The overall age-adjusted mortality rate increased from 16.5/100,000 in 1999 to 30.5/100,000 in 2018. AD mortality is projected to reach 42.40/100000 within the year 2023. Overall, AD resulted in 322,773.00 YLL (2.33 per 1000 population) in 1999 and 658,501.87 YLL (3.68 per 1000 population) in 2018. Conclusion: Our findings demonstrate an increase in AD mortality in the U.S. from 1999 to 2018 as well as a rapid increase from 2019 to 2023. The high burden of AD deaths emphasizes the need for targeted prevention, early diagnosis, and hierarchical management.
RAS ID
39666
Document Type
Journal Article
Date of Publication
2021
Volume
82
Issue
2
PubMed ID
34092643
School
School of Medical and Health Sciences / School of Business and Law
Copyright
subscription content
Publisher
IOS Press
Recommended Citation
Zhao, X., Li, C., Ding, G., Heng, Y., Li, A., Wang, W., Hou, H., Wen, J., & Zhang, Y. (2021). The burden of Alzheimer's disease mortality in the United States, 1999-2018. DOI: https://doi.org/10.3233/JAD-210225
Comments
Zhao, X., Li, C., Ding, G., Heng, Y., Li, A., Wang, W., . . . Zhang, Y. (2021). The burden of Alzheimer's disease mortality in the United States, 1999-2018. Journal of Alzheimer's Disease, 82(2), 803-813. https://doi.org/10.3233/JAD-210225