Author Identifier

Lauren Blekkenhorst

ORCID : 0000-0003-1561-9052

Document Type

Journal Article

Publication Title

Nutrients

Volume

13

Issue

8

Publisher

MDPI

School

School of Medical and Health Sciences

RAS ID

39744

Funders

National Health and Medical Research Council National Heart Foundation of Australia Post-Doctoral Research Fellowship

Grant Number

NHMRC Number : 1172987

Comments

Wehrli, F., Taneri, P. E., Bano, A., Bally, L., Blekkenhorst, L. C., Bussler, W., . . . Kern, H. (2021). Oat intake and risk of type 2 diabetes, cardiovascular disease and all-cause mortality: A systematic review and meta-analysis. Nutrients, 13(8), article 2560. https://doi.org/10.3390/nu13082560

Abstract

Cardiovascular disease (CVD) and type 2 diabetes (T2D) remain the top disease and mortality burdens worldwide. Oats have been shown to benefit cardiovascular health and improve insulin resistance. However, the evidence linking oat consumption with CVD, T2D and all-cause mortality remains inconclusive. We conducted a comprehensive systematic review and meta-analysis of prospective cohort studies to evaluate the associations between oat consumption and risks of T2D, CVD and all-cause mortality in the general population. Five electronic databases were searched until September, 2020. Study specific relative risks (RR) were meta-analyzed using random effect models. Of 4686 relevant references, we included 9 articles, based on 8 unique studies and 471,157 participants. Comparing oat consumers versus non-consumers, RRs were 0.86 (95% CI 0.72– 1.03) for T2D incidence and 0.73 (95% CI 0.5–1.07) for combined CVD incidence. Comparing participants with highest versus lowest oat intake, RRs were 0.78 (95% CI 0.74–0.82) for T2D incidence, 0.81 (95% CI 0.61–1.08) for CHD incidence and 0.79 (95% CI 0.59–1.07) for stroke. For all-cause mortality one study based on three cohorts found RR for men and women were 0.76 (95% CI 0.69–0.85) and 0.78 (95% CI 0.70–0.87), respectively. Most studies (n = 6) were of fair to good quality. This meta-analysis suggests that consumption of oat could reduce the risk for T2D and all-cause mortality, while no significant association was found for CVD. Future studies should address a lack of standardized methods in assessing overall oat intake and type of oat products, and investigate a dose-dependent response of oat products on cardiometabolic outcomes in order to introduce oat as preventive and treatment options for the public.

DOI

10.3390/nu13082560

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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