Document Type
Journal Article
Publication Title
Scientific Reports
Volume
11
Issue
1
Publisher
Nature
School
School of Medical and Health Sciences / Centre for Exercise and Sports Science Research / Exercise Medicine Research Institute
RAS ID
37019
Funders
Ministry of Science and Technology, Taiwan Ministry of Education, Taiwan
Abstract
This study compared changes in plasma complement component 1q (C1q), apelin and adropin concentrations in older obese women after descending (DSW) and ascending stair walking (ASW) training (n = 15/group) performed twice a week for 12 weeks, with gradual increases in exercise time from 5 to 60 min. Fasting blood samples were collected 3 days before the first and 4 days after the last training session. The improvements in the maximal voluntary isometric contraction (MVIC) strength of the knee extensors, functional physical fitness [e.g., 30-s chair stand (CS) performance], resting systolic blood pressure (SBP), insulin sensitivity [e.g., oral glucose tolerance test (OGTT)] and blood lipid profiles [e.g., total cholesterol (TC)] were greater (p < 0.05) in the DSW than ASW group. Plasma C1q decreased (− 51 ± 30%), and apelin (23 ± 15%) and adropin (127 ± 106%) increased (p ≤ .0.05) only after DSW. Significant (p ≤ 0.01) partial correlations were found between the pre- to post-DSW changes in C1q, apelin or adropin and changes in outcome measures [e.g., C1q and MVIC (r = − 0.837), apelin and SBP (r = − 0.854), and andropin and OGTT (r = − 0.729)]. These results showed that greater decreases in plasma C1q and greater increases in apelin and adropin concentrations were associated with greater improvements in outcome measures after DSW than after ASW.
DOI
10.1038/s41598-021-96631-x
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Chen, T. C., Huang, T. H., Tseng, W. C., Tseng, K. W., Hsieh, C. C., Chen, M. Y., . . . Nosaka, K. (2021). Changes in plasma C1q, apelin and adropin concentrations in older adults after descending and ascending stair walking intervention. Scientific Reports, 11, aricle 17644. https://doi.org/10.1038/s41598-021-96631-x