Document Type

Journal Article

Publication Title

Scientific Reports

Volume

11

Issue

1

Publisher

Nature

School

School of Medical and Health Sciences / Centre for Exercise and Sports Science Research / Exercise Medicine Research Institute

RAS ID

37019

Funders

Ministry of Science and Technology, Taiwan Ministry of Education, Taiwan

Comments

Chen, T. C., Huang, T. H., Tseng, W. C., Tseng, K. W., Hsieh, C. C., Chen, M. Y., . . . Nosaka, K. (2021). Changes in plasma C1q, apelin and adropin concentrations in older adults after descending and ascending stair walking intervention. Scientific Reports, 11, aricle 17644. https://doi.org/10.1038/s41598-021-96631-x

Abstract

This study compared changes in plasma complement component 1q (C1q), apelin and adropin concentrations in older obese women after descending (DSW) and ascending stair walking (ASW) training (n = 15/group) performed twice a week for 12 weeks, with gradual increases in exercise time from 5 to 60 min. Fasting blood samples were collected 3 days before the first and 4 days after the last training session. The improvements in the maximal voluntary isometric contraction (MVIC) strength of the knee extensors, functional physical fitness [e.g., 30-s chair stand (CS) performance], resting systolic blood pressure (SBP), insulin sensitivity [e.g., oral glucose tolerance test (OGTT)] and blood lipid profiles [e.g., total cholesterol (TC)] were greater (p < 0.05) in the DSW than ASW group. Plasma C1q decreased (− 51 ± 30%), and apelin (23 ± 15%) and adropin (127 ± 106%) increased (p ≤ .0.05) only after DSW. Significant (p ≤ 0.01) partial correlations were found between the pre- to post-DSW changes in C1q, apelin or adropin and changes in outcome measures [e.g., C1q and MVIC (r = − 0.837), apelin and SBP (r = − 0.854), and andropin and OGTT (r = − 0.729)]. These results showed that greater decreases in plasma C1q and greater increases in apelin and adropin concentrations were associated with greater improvements in outcome measures after DSW than after ASW.

DOI

10.1038/s41598-021-96631-x

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Research Themes

Society and Culture

Priority Areas

Human movement and performance

Share

 
COinS