Therapeutic potential of mitophagy-inducing microflora metabolite, urolithin a for Alzheimer’s disease

Authors

Dona Pamoda W. Jayatunga, Edith Cowan UniversityFollow
Eugene Hone, Edith Cowan UniversityFollow
Harjot Khaira
Taciana Lunelli
Harjinder Singh
Gilles J. Guillemin
Binosha Fernando, Edith Cowan UniversityFollow
Manohar L. Garg
Giuseppe Verdile, Edith Cowan UniversityFollow
Ralph N. Martins, Edith Cowan UniversityFollow

Author Identifier

Dona Pamoda Wajirapanie Jayatunga

ORCID : 0000-0002-7562-4294

Eugene Hone

ORCID : 0000-0001-6708-3718

Warnakulasuriya Fernando

ORCID : 0000-0002-8364-7808

Document Type

Journal Article

Publication Title

Nutrients

Volume

13

Issue

11

Publisher

MDPI

School

School of Medical and Health Sciences / Centre of Excellence for Alzheimer's Disease Research and Care

RAS ID

42754

Comments

Jayatunga, D. P. W., Hone, E., Khaira, H., Lunelli, T., Singh, H., Guillemin, G. J., . . . Martins, R. N. (2021). Therapeutic potential of mitophagy-inducing microflora metabolite, urolithin a for Alzheimer’s disease. Nutrients, 13(11), article 3744. https://doi.org/10.3390/nu13113744

Abstract

Mitochondrial dysfunction including deficits of mitophagy is seen in aging and neuro-degenerative disorders including Alzheimer’s disease (AD). Apart from traditionally targeting amyloid beta (Aβ), the main culprit in AD brains, other approaches include investigating impaired mitochondrial pathways for potential therapeutic benefits against AD. Thus, a future therapy for AD may focus on novel candidates that enhance optimal mitochondrial integrity and turnover. Bi-oactive food components, known as nutraceuticals, may serve as such agents to combat AD. Uro-lithin A is an intestinal microbe-derived metabolite of a class of polyphenols, ellagitannins (ETs). Urolithin A is known to exert many health benefits. Its antioxidant, anti-inflammatory, anti-athero-genic, anti-Aβ, and pro-mitophagy properties are increasingly recognized. However, the underly-ing mechanisms of urolithin A in inducing mitophagy is poorly understood. This review discusses the mitophagy deficits in AD and examines potential molecular mechanisms of its activation. More-over, the current knowledge of urolithin A is discussed, focusing on its neuroprotective properties and its potential to induce mitophagy. Specifically, this review proposes potential mechanisms by which urolithin A may activate and promote mitophagy.

DOI

10.3390/nu13113744

Related Publications

Jayatunga, D. (2020). Investigation of selected nutraceuticals to protect against mitochondrial dysfunction: Potential therapeutic role in Alzheimer’s disease. https://ro.ecu.edu.au/theses/2368

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This work is licensed under a Creative Commons Attribution 4.0 License.