Author Identifier
Lauren Blekkenhorst
ORCID : 0000-0003-1561-9052
Joshua Lewis
ORCID : 0000-0003-1003-8443
Jonathan Hodgson
ORCID : 0000-0001-6184-7764
Marc Sim
ORCID : 0000-0001-5166-0605
Document Type
Journal Article
Publication Title
Frontiers in Nutrition
Publisher
Frontiers Media S.A.
School
School of Medical and Health Sciences / Institute for Nutrition Research
RAS ID
39844
Funders
Edith Cowan University - Open Access Support Scheme 2021
Perth Royal Hospital
National Health and Medical Research Council
National Heart Foundation of Australia
Grant Number
NHMRC Number : 1172987, 1116973
Abstract
Vitamin K content of foods is known to vary substantially by geographical location. In Australia, no Vitamin K database of food exists, thereby creating ambiguity when trying to develop national dietary intake guidelines. This investigation aimed to develop a Vitamin K database for commonly consumed foods that are commercially available in Australian supermarkets. The Vitamin K1 (phylloquinone; PK) and K2 (menaquinone; MK4, MK7) content of 60 foods known to contain Vitamin K were assessed (e.g., vegetables fruits, oils, animal products, dairy and fermented foods). A liquid chromatography with tandem mass spectrometry (LCMS/MS) method was developed and used to measure PK and MKs in different foods with an improved chromatographic separation and detection of Vitamin K's and their analogs. The LOD and LOQ for PK and MK4 was 0.1, 0.5 ng/ml and 0.5, 1.0 ng/ml, respectively. The majority foods contained detectable PK (53/60), about half contained MK4 (31/60), and few contained MK7 (3/60). PK was highest in green leafy vegetables, with moderate amounts in oils. Highest MK4 content was in chicken eggs and meat products such as ham and chicken. This database enables nutritional epidemiologist to estimate dietary Vitamin K intake, especially in Australian cohorts, for a range of health outcomes.
DOI
10.3389/fnut.2021.753059
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Palmer, C. R., Koch, H., Shinde, S., Blekkenhorst, L. C., Lewis, J. R., Croft, K. D., . . . Sim, M. (2021). Development of a vitamin K database for commercially available food in Australia. Frontiers in Nutrition, 8, article 753059. https://doi.org/10.3389/fnut.2021.753059