Longitudinal association of intraindividual variability with cognitive decline and dementia: A meta-analysis

Document Type

Journal Article

Publication Title

Neuropsychology

Volume

35

Issue

7

First Page

669

Last Page

678

PubMed ID

34410816

Publisher

American Psychological Association

School

School of Medical and Health Sciences

RAS ID

42705

Funders

University of Western Australia

Comments

Mumme, R., Pushpanathan, M., Donaldson, S., Weinborn, M., Rainey-Smith, S. R., Maruff, P., & Bucks, R. (2021). Longitudinal association of intraindividual variability with cognitive decline and dementia: A meta-analysis. Neuropsychology, 35(7), 669-678. https://doi.org/10.1037/neu0000746

Abstract

Objective: Intraindividual variability (IIV)—variance in an individual's cognitive performance—may be associated with subsequent cognitive decline and/or conversion to dementia in older adults. This novel measure of cognition encompasses two main operationalizations: inconsistency (IIV-I) and dispersion (IIV-D), referring to variance within or across tasks, respectively. Each operationalization can also be measured with or without covariates. This meta-analytic study explores the association between IIV and subsequent cognitive outcomes regardless of operational definition and measurement approach. Method: Longitudinal studies (N = 13) that have examined IIVin association with later cognitive decline and/or conversation toMCI/ dementia were analyzed. The effect of IIV operationalization was explored. Additional subgroup analysis of measurement approaches could not be examined due to the limited number of appropriate studies available for inclusion. Results: Meta-analytic estimates suggest IIV is associated with subsequent cognitive decline and/or conversion to MCI/dementia (r =.20, 95% CI [.09,.31]) with no significant difference between the two operationalizations, appears to be associated with subsequent cognitive decline and/or dementia andmay offer a novel indicator of incipient dementia in both clinical and research settings.

DOI

10.1037/neu0000746

Access Rights

subscription content

Link to Full Text

Share

 
COinS