Longitudinal association of intraindividual variability with cognitive decline and dementia: A meta-analysis
Abstract
Objective: Intraindividual variability (IIV)—variance in an individual's cognitive performance—may be associated with subsequent cognitive decline and/or conversion to dementia in older adults. This novel measure of cognition encompasses two main operationalizations: inconsistency (IIV-I) and dispersion (IIV-D), referring to variance within or across tasks, respectively. Each operationalization can also be measured with or without covariates. This meta-analytic study explores the association between IIV and subsequent cognitive outcomes regardless of operational definition and measurement approach. Method: Longitudinal studies (N = 13) that have examined IIVin association with later cognitive decline and/or conversation toMCI/ dementia were analyzed. The effect of IIV operationalization was explored. Additional subgroup analysis of measurement approaches could not be examined due to the limited number of appropriate studies available for inclusion. Results: Meta-analytic estimates suggest IIV is associated with subsequent cognitive decline and/or conversion to MCI/dementia (r =.20, 95% CI [.09,.31]) with no significant difference between the two operationalizations, appears to be associated with subsequent cognitive decline and/or dementia andmay offer a novel indicator of incipient dementia in both clinical and research settings.
Document Type
Journal Article
Date of Publication
2021
Volume
35
Issue
7
PubMed ID
34410816
Publication Title
Neuropsychology
Publisher
American Psychological Association
School
School of Medical and Health Sciences
RAS ID
42705
Funders
University of Western Australia
Copyright
subscription content
First Page
669
Last Page
678
Comments
Mumme, R., Pushpanathan, M., Donaldson, S., Weinborn, M., Rainey-Smith, S. R., Maruff, P., & Bucks, R. (2021). Longitudinal association of intraindividual variability with cognitive decline and dementia: A meta-analysis. Neuropsychology, 35(7), 669-678. https://doi.org/10.1037/neu0000746