The rapidly expanding nexus of immunoglobulin G N-glycomics, suboptimal health status, and precision medicine

Document Type

Book Chapter

Publication Title

Antibody Glycosylation

Volume

112

First Page

545

Last Page

564

PubMed ID

34687022

Publisher

Springer

School

School of Medical and Health Sciences / Centre for Precision Health

RAS ID

39841

Funders

Australia-China International Collaborative Grant

Comments

Russell, A., & Wang, W. (2021). The rapidly expanding nexus of immunoglobulin G N-glycomics, suboptimal health status, and precision medicine. In M. Pezer (Ed.), Antibody Glycosylation (pp. 545-564). Springer, Cham.

https://doi.org/10.1007/978-3-030-76912-3_17

Abstract

Immunoglobulin G is a prevalent glycoprotein, whose downstream immune responses are partially mediated by the N-glycans within the fragment crystallisable domain. Collectively termed the N-glycome, it is considered a complex intermediate phenotype: an amalgamation of genetic predisposition, environmental exposure, and health behaviours over the life-course. Thus, the immunoglobulin G N-glycome may provide an indication of health status on the spectrum from health to disease and infirmary. Although variability exists within and between populations, composition of the immunoglobulin G N-glycome remains stable over short periods of time. This underscores the potential of harnessing the immunoglobulin G N-glycome as an ideal tool for preclinical disease risk prediction, stratification, and prognosis through the development of precise dynamic biomarkers.

DOI

10.1007/978-3-030-76912-3_17

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