The rapidly expanding nexus of immunoglobulin G N-glycomics, suboptimal health status, and precision medicine
Abstract
Immunoglobulin G is a prevalent glycoprotein, whose downstream immune responses are partially mediated by the N-glycans within the fragment crystallisable domain. Collectively termed the N-glycome, it is considered a complex intermediate phenotype: an amalgamation of genetic predisposition, environmental exposure, and health behaviours over the life-course. Thus, the immunoglobulin G N-glycome may provide an indication of health status on the spectrum from health to disease and infirmary. Although variability exists within and between populations, composition of the immunoglobulin G N-glycome remains stable over short periods of time. This underscores the potential of harnessing the immunoglobulin G N-glycome as an ideal tool for preclinical disease risk prediction, stratification, and prognosis through the development of precise dynamic biomarkers.
Document Type
Book Chapter
Date of Publication
1-1-2021
Volume
112
PubMed ID
34687022
Publication Title
Antibody Glycosylation
Publisher
Springer
School
School of Medical and Health Sciences / Centre for Precision Health
RAS ID
39841
Funders
Australia-China International Collaborative Grant
Copyright
subscription content
First Page
545
Last Page
564
Comments
Russell, A., & Wang, W. (2021). The rapidly expanding nexus of immunoglobulin G N-glycomics, suboptimal health status, and precision medicine. In M. Pezer (Ed.), Antibody Glycosylation (pp. 545-564). Springer, Cham.
https://doi.org/10.1007/978-3-030-76912-3_17