Circulating Lipocalin 2 Levels Predict Fracture-Related Hospitalizations in Elderly Women: A Prospective Cohort Study
Document Type
Journal Article
Publisher
John Wiley and Sons Inc.
School
School of Exercise and Health Sciences
RAS ID
20784
Abstract
Lipocalin 2 (LCN2) or neutrophil gelatinase-associated lipocalin (NGAL) is expressed in a wide range of cells and pathological states. Mounting evidence suggests lipocalin 2 may be an important regulator of bone homeostasis. Recently it has been suggested LCN2 is a novel mechanoresponsive gene central to the pathological response to low mechanical force. We undertook a prospective study of 1009 elderly women over 70 years of age to study the association between circulating LCN2 and potential associated variables, including estimated glomerular filtration rate, physical activity, and baseline measures of hip bone density and heel bone quality. Osteoporotic fractures requiring hospitalizations were identified from the Western Australian Data Linkage System. Over 14.5 years, 272 (27%) of women sustained an osteoporotic fracture-related hospitalization; of these, 101 were hip fractures. Circulating LCN2 levels were correlated with body mass index and estimated glomerular filtration rate (r=0.249, p
DOI
10.1002/jbmr.2546
Access Rights
free_to_read
Comments
Lim, W.H., Wong, G., Lim, E.M., Byrnes, E., Zhu, K., Devine, A., Pavlos, N.J., Prince, R.L., Lewis, J.R. (2015). Circulating Lipocalin 2 Levels Predict Fracture-Related Hospitalizations in Elderly Women: A Prospective Cohort Study in Journal of Bone and Mineral Research, 30(11), 2078-2085. Available here.