Effects of branched-chain amino acids supplementation on both plasma amino acids concentration and muscle energetics changes resulting from muscle damage: A randomized placebo controlled trial

Abstract

Background & aims: Branched-chain amino acids promote muscle-protein synthesis, reduce protein oxidation and have positive effects on mitochondrial biogenesis and reactive oxygen species scavenging. The purpose of the study was to determine the potential benefits of branched-chain amino acids supplementation on changes in force capacities, plasma amino acids concentration and muscle metabolic alterations after exercise-induced muscle damage. Methods: 31P magnetic resonance spectroscopy and biochemical analyses were used to follow the changes after such damage. Twenty six young healthy men were randomly assigned to supplemented branched-chain amino acids or placebo group. Knee extensors maximal voluntary isometric force was assessed before and on four days following exercise-induced muscle damage. Concentrations in phosphocreatine [PCr], inorganic phosphate [Pi] and pH were measured during a standardized rest-exercise-recovery protocol before, two (D2) and four (D4) days after exercise-induced muscle damage. Results: No significant difference between groups was found for changes in maximal voluntary isometric force (−24% at D2 and −21% at D4). Plasma alanine concentration significantly increased immediately after exercise-induced muscle damage (+25%) in both groups while concentrations in glycine, histidine, phenylalanine and tyrosine decreased. No difference between groups was found in the increased resting [Pi] (+42% at D2 and +34% at D4), decreased resting pH (−0.04 at D2 and −0.03 at D4) and the slower PCr recovery rate (−18% at D2 and −24% at D4). Conclusions: The damaged muscle was not able to get benefits out of the increased plasma branched-chain amino acids availability to attenuate changes in indirect markers of muscle damage

Document Type

Journal Article

Date of Publication

2016

Location of the Work

Netherlands

Publication Title

Clinical Nutrition

Publisher

Elsevier

School

Centre for Exercise and Sport Science Research / School of Exercise and Health Sciences

RAS ID

20642

Comments

Fouré, A., Nosaka, K., Gastaldi, M., Mattei, J. P., Boudinet, H., Guye, M., . . . Gondin, J. (2016). Effects of branched-chain amino acids supplementation on both plasma amino acids concentration and muscle energetics changes resulting from muscle damage: A randomized placebo controlled trial. Clinical Nutrition, 35(1), 83-94. Available here.

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Link to publisher version (DOI)

10.1016/j.clnu.2015.03.014