The association between ankle-brachial index and asymptomatic cranial-carotid stenosis: A population-based, cross-sectional study of 5440 Han Chinese

Document Type

Journal Article

Publication Title

European Journal of Neurology

Publisher

Blackwell Publishing Ltd

School

School of Medical Sciences

RAS ID

23310

Comments

Qiu, J., Zhou, Y., Yang, X., Zhang, Y., Li, Z., Yan, N., . . . Wang, W. (2016). The association between ankle-brachial index and asymptomatic cranial-carotid stenosis: A population-based, cross-sectional study of 5440 Han Chinese. European Journal of Neurology, 23(4), 757-762. Available here

Abstract

Background and purpose: Routine screening for asymptomatic cranial-carotid stenosis (ACCS) is controversial and recommendation in clinical practice is vague. The ankle-brachial index (ABI) is reported as a predictor for cardiovascular disease. However, there is a scarcity of data about the association between abnormal ABI and ACCS. A population-based cross-sectional study was conducted to explore the relationship between ABI and ACCS. Methods: A sample of 5440 Chinese adults aged 40-94 years old was recruited from 2010 to 2011. The ABI was measured using a portable Doppler device and ACCS was evaluated by bilateral carotid duplex ultrasound and portable examination devices. A logistic regression model was used to analyse the association between ABI and ACCS after adjusting for potential confounding factors. Results: A low ABI was associated with ACCS [odds ratio (OR) 1.95, 95% confidence interval (CI) 1.42-2.67] after adjusting for potential confounders. When the data were stratified by age and sex, the correlation remained statistically significant in the male (OR 2.32, 95% CI 1.60-3.37) and elderly (OR 3.07, 95% CI 1.97-4.78) subgroups compared to the female (OR 1.26, 95% CI 0.67-2.39) and middle-aged groups (OR 1.27, 95% CI 0.77-2.12), respectively. Conclusion: This study demonstrated that low ABI is a significant risk factor for ACCS in male and elderly Chinese adults. © 2016.

DOI

10.1111/ene.12935

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