Document Type
Journal Article
Publisher
Editorial Board of Neural Regeneration Research
School
School of Medical Sciences
RAS ID
21827
Abstract
Few would doubt that understanding the developmental landscape from which a mature neuron is derived is essential to understand its biology. The temporal and spatial position of a cell from the very earliest stages of development predicts the unique combinations of growth factors it will subsequently be exposed to. This combination of factors determines the transcriptional platform set within the cell by its specific combination of transcription factors, who direct the show. This, in turn, determines what cell type it will differentiate into, and what connections it will make. How this developmental platform translates to maintenance of a differentiated neuron in an adult brain is less clear.
DOI
10.4103/1673-5374.175044
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.
Comments
White, R. B., & Thomas, M. G. (2016). Developmental transcription factors in age-related CNS disease: a phoenix rising from the ashes?. Neural Regeneration Research, 11(1), 64.
https://doi.org/10.4103/1673-5374.175044