SFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease

Document Type

Journal Article

Publication Title

The International Journal of Biochemistry & Cell Biology

Publisher

Elsevier

School

School of Medical Sciences / Centre of Excellence for Alzheimer's Disease Research and Care

RAS ID

24468

Comments

Warrier, S., Marimuthu, R., Sekhar, S., Bhuvanalakshmi, G., Arfuso, F., Das, A. K., . . . Dharmarajan. (2016). sFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer’s disease. The International Journal of Biochemistry & Cell Biology, 75, 104-111. Available here

Abstract

The extracellular ligand, Wnt, and its receptors are involved in sign al transduction and play an important role in axis formation and neural development. In neurodegenerative disorders such as Alzheimer's disease (AD), a decrease of the intracellular Wnt effector, β-catenin, has been linked to amyloid-β-peptide-induced neurotoxicity. Despite this knowledge, targeting Wnt inhibitors as potential biomarkers has not been explored, and harnessing Wnt activators as therapeutic candidates remains largely not investigated. A wide acting family of Wnt mediators, secreted frizzled-related proteins (sFRPs), has not been probed so far as molecular indicators of disease occurrence and progression of Alzheimer's. Unlike the effect of the Dickkopf (DKK) family of Wnt antagonists on AD, the sFRP molecules have a more pleiotropic impact on the Wnt signaling cascade and probably have a far-reaching involvement in neurodegeneration. The role of sFRPs has been poorly described in AD, and in this review, we analyze the present status of the role of sFRPs on neurodegeneration, their likely involvement, and potential implications in treatment modalities of AD. This information would provide valuable clues for the development of potential therapeutic targets for aberrant neurodegenerative disorders. © 2016 Elsevier Ltd. All rights reserved.

DOI

10.1016/j.biocel.2016.04.002

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