Enhancing active surveillance of prostate cancer: The potential of exercise medicine
Authors
Daniel A. Galvao, Edith Cowan UniversityFollow
Dennis Taaffe, Edith Cowan UniversityFollow
Nigel Spry, Edith Cowan UniversityFollow
Robert Gardiner, Edith Cowan UniversityFollow
Renea Taylor
Gail Risbridger
Mark Frydenberg
Michelle Hill
Suzanne K. Chambers, Edith Cowan UniversityFollow
Phillip Stricker
Tom Shannon
Dickon Hayne
Eva Zopf, Edith Cowan UniversityFollow
Robert Newton, Edith Cowan UniversityFollow
Document Type
Journal Article
Publication Title
Nature Reviews Urology
Publisher
Nature
School
Exercise Medicine Research Institute
RAS ID
22025
Abstract
Active surveillance (AS) is a strategy for the management of patients with low-risk, localized prostate cancer, in which men undergo regular monitoring of serum PSA levels and tumour characteristics, using multiparametric MRI and repeat biopsy sampling, to identify signs of disease progression. This strategy reduces overtreatment of clinically insignificant disease while also preserving opportunities for curative therapy in patients whose disease progresses. Preliminary studies of lifestyle interventions involving basic exercise advice have indicated that exercise reduces the numbers of patients undergoing active treatment, as well as modulating the biological processes involved in tumour progression. Therefore, preliminary evidence suggests that lifestyle and/or exercise interventions might have therapeutic potential in this growing population of men with prostate cancer. However, several important issues remain unclear: the exact value of different types of lifestyle and exercise medicine interventions during AS; the biological mechanisms of exercise in delaying disease progression; and the influence of the anxieties and distress created by having a diagnosis of cancer without then receiving active treatment. Future studies are required to confirm and expand these findings and determine the relative contributions of each lifestyle component to specific end points and patient outcomes during AS. © 2016 Macmillan Publishers Limited. All rights reserved.
DOI
10.1038/nrurol.2016.46
Access Rights
subscription content
Comments
Galvão, D. A., Taaffe, D. R., Spry, N., Gardiner, R. A., Taylor, R., Risbridger, G. P., . . . Newton, R. U. (2016). Enhancing active surveillance of prostate cancer: The potential of exercise medicine. Nature Reviews Urology, 13, 258-265. Available here