Abstract
A link between autoimmune responses and cancer via autoantibodies was first described in the 1950s. Since, autoantibodies have been studied for their potential use as cancer biomarkers, however the exact causes of their production remain to be elucidated. This review summarizes current theories of the causes of autoantibody production in cancer, namely:
1) defects in tolerance and inflammation,
2) changes in protein expression levels,
3) altered protein structure, and
4) cellular death mechanisms.
We also highlight the need for further research into this field to improve our understanding of autoantibodies as biomarkers for cancer development and progression.
Document Type
Journal Article
Date of Publication
2016
Publisher
Elsevier
School
School of Medical and Health Sciences
RAS ID
21454
Funders
Edith Cowan University - Inspiring Minds scholarship
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Zaenker, P., Gray, E. S., & Ziman, M. R. (2016). Autoantibody Production in Cancer—The Humoral Immune Response toward Autologous Antigens in Cancer Patients. Autoimmunity reviews, 15(5), 477-483.
https://doi.org/10.1016/j.autrev.2016.01.017