Document Type
Journal Article
Publisher
Nature Publishing Group
School
School of Medical and Health Sciences
RAS ID
21156
Funders
National Health and Medical Research Council (NHMRC) of Australia (Grant number: 491164)
Eva and Les Erdi Foundation
Faculty of Medicine, Nursing and Health Sciences, Monash University, scholarship
Grant Number
NHMRC Number : 491164
Abstract
OBJECTIVES:
Altering FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides and polyols) intake has substantial effects on gut microbiota. This study aimed to investigate effects of altering FODMAP intake on markers of colonic health in patients with Crohn’s disease.
METHODS:
After evaluation of their habitual diet, 9 patients with clinically quiescent Crohn’s disease were randomised to 21 days of provided low or typical (“Australian”) FODMAP diets with ≥ 21-day washout in between. Five-day fecal samples were collected at the end of each diet and analyzed for calprotectin, pH, short-chain fatty acids (SCFA) and bacterial abundance. Gastrointestinal symptoms were recorded daily.
RESULTS:
Eight participants collected feces and were adherent to the diets. FODMAP intake differed across the three dietary periods with lowohabitualoAustralian diet. SCFA, pH and total bacterial abundance remained unaltered, but relative abundance was higher for butyrate-producing Clostridium cluster XIVa (P = 0.008) and mucus-associated Akkermansia muciniphila (P = 0.016), and lower for Ruminococcus torques (P = 0.034) during the Australian compared with low FODMAP diet. Results during habitual diet were similar to the low FODMAP intervention, but significantly different to the Australian diet. The diets had no effects on calprotectin, but symptoms doubled in severity with the Australian diet (n = 9; Po0.001).
CONCLUSIONS:
In clinically quiescent Crohn’s disease, altering dietary FODMAP intake is associated with marked changes in fecal microbiota, most consistent with a prebiotic effect of increasing FODMAPs as shown in an irritable bowel/healthy cohort. This strategy might be favorable for gut health in Crohn’s disease, but at the cost of inducing symptoms.
DOI
10.1038/ctg.2016.22
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Comments
Halmos, E. P., Christophersen, C. T., Bird, A. R., Shepherd, S. J., Muir, J. G., & Gibson, P. R. (2016). Consistent Prebiotic Effect on Gut Microbiota With Altered FODMAP Intake in Patients with Crohn’s Disease: A Randomised, Controlled Cross-Over Trial of Well-Defined Diets. Clinical and translational gastroenterology, 7(4), e164.
https://doi.org/10.1038/ctg.2016.22