The relationship between sleep quality and brain amyloid burden
Authors
Belinda M. Brown, Edith Cowan UniversityFollow
Stephanie Rainey-Smith, Edith Cowan UniversityFollow
Victor L. Villemagne, Austin Health, Department of Nuclear Medicine and Centre for PET, Heidelberg
Michael Weinborn, Edith Cowan UniversityFollow
Romola S. Bucks, University of Western Australia
Hamid R. Sohrabi, Edith Cowan UniversityFollow
Simon M. Laws, Edith Cowan UniversityFollow
Kevin Taddei, Edith Cowan UniversityFollow
Lance Macaulay, CSIRO
David Ames, University of Melbourne
Christopher Fowler, University of Melbourne
Paul Maruff, University of Melbourne
Colin L. Masters, University of Melbourne
Christopher Rowe, Austin Health, Department of Neclear Medicing and Centre for PET, Heidleberg
Ralph Martins, Edith Cowan UniversityFollow
Document Type
Journal Article
Publication Title
Sleep
Publisher
Associated Professional Sleep Societies,LLC
Place of Publication
Westchester, USA
School
School of Medical and Health Sciences
RAS ID
21241
Abstract
To evaluate the association between self-reported sleep quality and levels of brain β-amyloid (Aβ) burden, and to determine the effect of the apolipoprotein E (APOE) ε4 allele on any associations found.This study is a cross-sectional analysis of 184 cognitively healthy men and women aged over 60 y. We measured sleep quality factors: specifically, sleep duration, latency (time taken to fall asleep), disturbances, efficiency, daytime dysfunction, and overall sleep quality, using the Pittsburgh Sleep Quality Index. All participants underwent Aβ positron emission tomography imaging for the quantification of brain Aβ burden and were APOE genotyped. Linear regression analyses were used to evaluate the relationship between sleep quality factors and brain Aβ burden, adjusting for age, body mass index, cardiovascular disease, and symptoms of depression, with APOE ε4 carriage entered as a moderator.Of the sleep factors, longer sleep latency was associated with higher levels of brain Aβ (B = 0.003 [standard error = 0.001], P = 0.02). APOE ε4 allele (carrier/noncarrier) did not moderate the relationship between sleep latency and brain Aβ burden.Our findings suggest a relationship between brain Aβ burden and sleep latency, independent of APOE ε4 genotype.
DOI
10.5665/sleep.5756
Access Rights
free_to_read
Comments
Brown, B. M., Rainey-Smith, S. R., Villemagne, V. L., Weinborn, M., Bucks, R. S., Sohrabi, H. R., ... Martins, R. N. (2016). The relationship between sleep quality and brain amyloid burden. Sleep, 39(5). 1063-1068. Available here