The relationship between sleep quality and brain amyloid burden

Authors/Creators

• Belinda M. Brown, Edith Cowan UniversityFollow
• Stephanie Rainey-Smith, Edith Cowan UniversityFollow
• Victor L. Villemagne, Austin Health, Department of Nuclear Medicine and Centre for PET, Heidelberg
• Michael Weinborn, Edith Cowan UniversityFollow
• Romola S. Bucks, University of Western Australia
• Hamid R. Sohrabi, Edith Cowan UniversityFollow
• Simon M. Laws, Edith Cowan UniversityFollow
• Kevin Taddei, Edith Cowan UniversityFollow
• Lance Macaulay, CSIRO
• David Ames, University of Melbourne
• Christopher Fowler, University of Melbourne
• Paul Maruff, University of Melbourne
• Colin L. Masters, University of Melbourne
• Christopher Rowe, Austin Health, Department of Neclear Medicing and Centre for PET, Heidleberg
• Ralph Martins, Edith Cowan UniversityFollow

Abstract

To evaluate the association between self-reported sleep quality and levels of brain β-amyloid (Aβ) burden, and to determine the effect of the apolipoprotein E (APOE) ε4 allele on any associations found.This study is a cross-sectional analysis of 184 cognitively healthy men and women aged over 60 y. We measured sleep quality factors: specifically, sleep duration, latency (time taken to fall asleep), disturbances, efficiency, daytime dysfunction, and overall sleep quality, using the Pittsburgh Sleep Quality Index. All participants underwent Aβ positron emission tomography imaging for the quantification of brain Aβ burden and were APOE genotyped. Linear regression analyses were used to evaluate the relationship between sleep quality factors and brain Aβ burden, adjusting for age, body mass index, cardiovascular disease, and symptoms of depression, with APOE ε4 carriage entered as a moderator.Of the sleep factors, longer sleep latency was associated with higher levels of brain Aβ (B = 0.003 [standard error = 0.001], P = 0.02). APOE ε4 allele (carrier/noncarrier) did not moderate the relationship between sleep latency and brain Aβ burden.Our findings suggest a relationship between brain Aβ burden and sleep latency, independent of APOE ε4 genotype.

Keywords

Alzheimer disease, apolipoprotein ε4 allele, beta-amyloid, sleep, sleep latency

Document Type

Journal Article

Date of Publication

2016

Location of the Work

Westchester, USA

Publication Title

Sleep

Publisher

Associated Professional Sleep Societies,LLC

School

School of Medical and Health Sciences

RAS ID

21241

Comments

Brown, B. M., Rainey-Smith, S. R., Villemagne, V. L., Weinborn, M., Bucks, R. S., Sohrabi, H. R., ... Martins, R. N. (2016). The relationship between sleep quality and brain amyloid burden. Sleep, 39(5). 1063-1068. Available here

Copyright

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