Document Type
Journal Article
Publisher
Omics Publishing Group
School
School of Medical and Health Sciences
RAS ID
22398
Abstract
Background:
Alterations in glycosylation patterns have long been known to reflect changes in cell metabolism. In this study, we investigated the relationship between human N-glycan profiles and metabolic syndrome.
Method:
Between 2005 and 2011, 2,155 individuals from the Orkney Islands (UK) were recruited and biological material, alongside phenotypic measures were collected. Individual N-glycan profiles were measured in plasma using weak anion exchange high performance liquid chromatography and calibrated hydrophilic interaction liquid chromatography. Pre-specified criteria were used to identify 564 cases with metabolic syndrome and 1475 controls. We applied logistic regression to test for association between this binary outcome against measured plasma N-glycans. We also assessed the correlation between N-glycan traits and individual components of metabolic syndrome and compared this to results found in similar analyses based in Chinese and Croatian populations.
Results:
21 N-glycan traits were found to be associated with either an increased or a decreased likelihood of participants having metabolic syndrome, including monosialylated plasma N-glycans (OR of 1.49 (95%CI 1.33, 1.67), q=1.26E-12) and core fucosylated plasma N-glycans (OR of 0.81(95% CI 0.72-0.90), q=7.75E-4). Notably, consistent results in both sections of this analysis demonstrated the protective association of higher levels of core fucosylated N-glycans.
Conclusion:
Our results demonstrate that metabolic syndrome is associated with an alteration in plasma N-glycosylation patterns. The metabolic role of core fucosylated N-glycans is of particular interest for future study.
DOI
10.4172/2153-0637.1000139
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
McLachlan, F., Timofeeva, M., Bermingham, M., Wild, S., & Rudan, I. (2016). A case-control study in an Orcadian population investigating the relationship between human plasma N-glycans and metabolic syndrome. Journal of Glycomics & Lipidomics, 6(3), pp. 2153-0637.
https://doi.org/10.4172/2153-0637.1000139