Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease
Authors/Creators
- Belinda M. Brown, Edith Cowan UniversityFollow
- Hamid R. Sohrabi, Edith Cowan UniversityFollow
- Kevin Taddei, Edith Cowan UniversityFollow
- Samantha Gardener, Edith Cowan UniversityFollow
- Stephanie Rainey-Smith, Edith Cowan UniversityFollow
- Jeremiah J. Peiffer
- Chengjie Xiong
- Anne M. Fagan
- Tammie Benzinger
- Virginia Buckles
- Kirk I. Erickson
- Roger Clarnette
- Tejal Shah
- Colin L. Masters
- Michael Weiner
- Nigel Cairns
- Martin Rossor
- Neill R. Graff-Radford
- Stephen Salloway
- Jonathan Vöglein
- Christoph Laske
- James Noble
- Peter R. Schofield
- Randall J. Bateman
- John C. Morris
- Ralph Martins, Edith Cowan UniversityFollow
Author Identifier (ORCID)
Belinda Brown
https://orcid.org/0000-0001-7927-2540
Hamid Reza Sohrabi
https://orcid.org/0000-0001-8017-8682
Kevin Taddei
https://orcid.org/0000-0002-8106-7957
Samantha L Gardener
https://orcid.org/0000-0002-1933-5260
Ralph Martins
Abstract
Introduction: The objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer’s disease (AD) biomarkers, in a cohort of autosomal dominant AD mutation carriers.
Methods: In 139 presymptomatic mutation carriers from the Dominantly Inherited Alzheimer Network, the relationship between self-reported exercise levels and brain amyloid load, cerebrospinal fluid (CSF) Ab42, and CSF tau levels was evaluated using linear regression.
Results: No differences in brain amyloid load, CSFAb42, or CSF tau were observed between low and high exercise groups. Nevertheless, when examining only those already accumulating AD pathology (i.e., amyloid positive), low exercisers had higher mean levels of brain amyloid than high exercisers. Furthermore, the interaction between exercise and estimated years from expected symptom onset was a significant predictor of brain amyloid levels.
Discussion: Our findings indicate a relationship exists between self-reported exercise levels and brain amyloid in autosomal dominant AD mutation carriers.
Keywords
Physical activity, Amyloid β, Genetics, Tau, Alzheimer’s disease, Dementia
Document Type
Journal Article
Date of Publication
2017
Publication Title
Alzheimer's & Dementia
Publisher
Elsevier
School
School of Medical and Health Sciences
RAS ID
25380
Funders
National Health and Medical Research Council
Grant Number
NHMRC Number : 1097105
Copyright
subscription content
Comments
Brown, B. M., Sohrabi, H. R., Taddei, K., Gardener, S. L., Rainey-Smith, S. R., Peiffer, J. J., . . . Erickson, K. I. (2017). Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease. Alzheimer's & Dementia, 13(11), 1197-1206. https://doi.org/10.1016/j.jalz.2017.03.008