Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes
Authors/Creators
Toma Keser
Ivan Gornik
Frano Vuckovic
Najda Selak
Tamara Pavic
Edita Lukic
Hrvoje Gasparovic
Bojan Biocina
Therese Tilin
Annika Wennerstrom
Satu Mannisto
Veikko Salomaa
Aki Havulinna
Wei Wang, Edith Cowan UniversityFollow
James F. Wilson
Nishi Charutvedi
Markus Perola
Harry Campbell
Gordan Lauc
Olga Gornik
Abstract
Better understanding of type 2 diabetes and its prevention is a pressing need. Changes in human plasma N-glycome are associated with many diseases and represent promising diagnostic and prognostic biomarkers. Variations in glucose metabolism directly affect glycosylation through the hexosamine pathway but studies of plasma glycome in type 2 diabetes are scarce. The aim of this study was to determine whether plasma protein N-glycome is changed in individuals who are at greater risk of developing type 2 diabetes.
RAS ID
25701
Document Type
Journal Article
Date of Publication
2017
Funding Information
National Health and Medical Research Council
School
School of Medical and Health Sciences
Grant Number
NHMRC Number : 1112767
Copyright
free_to_read
Publisher
Springer Verlag
Comments
Keser T., Gornik I., Vučković F., Selak N., Pavić T., Lukić E., Gudelj I., Gašparović H., ... Gornik O. (2017). Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes. Diabetologia, 60(12), 2352-2360. Available here.