Title

Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes

Document Type

Journal Article

Publisher

Springer Verlag

School

School of Medical and Health Sciences

RAS ID

25701

Grant Number

NHMRC Number : 1112767

Comments

Originally published as: Keser T., Gornik I., Vučković F., Selak N., Pavić T., Lukić E., Gudelj I., Gašparović H., ... Gornik O. (2017). Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes. Diabetologia, 60(12), 2352-2360. Original article available here.

Abstract

Better understanding of type 2 diabetes and its prevention is a pressing need. Changes in human plasma N-glycome are associated with many diseases and represent promising diagnostic and prognostic biomarkers. Variations in glucose metabolism directly affect glycosylation through the hexosamine pathway but studies of plasma glycome in type 2 diabetes are scarce. The aim of this study was to determine whether plasma protein N-glycome is changed in individuals who are at greater risk of developing type 2 diabetes.

DOI

10.1007/s00125-017-4426-9

Access Rights

free_to_read

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