Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes
Wei Wang, Edith Cowan UniversityFollow
James F. Wilson
School of Medical and Health Sciences
National Health and Medical Research Council
NHMRC Number : 1112767
Better understanding of type 2 diabetes and its prevention is a pressing need. Changes in human plasma N-glycome are associated with many diseases and represent promising diagnostic and prognostic biomarkers. Variations in glucose metabolism directly affect glycosylation through the hexosamine pathway but studies of plasma glycome in type 2 diabetes are scarce. The aim of this study was to determine whether plasma protein N-glycome is changed in individuals who are at greater risk of developing type 2 diabetes.