The association between red cell distribution width, erythropoietin levels, and coronary artery disease
Document Type
Journal Article
Publication Title
Coronary Artery Disease
Publisher
Lippincott Williams and Wilkins
Place of Publication
United States
School
School of Medical Sciences
RAS ID
45137
Abstract
Background: Red cell distribution width (RDW) is a cardiac marker for risk stratification and prognostic evaluation of coronary artery disease (CAD); however, the underlying mechanism remains unclear. Erythropoietin (EPO), a crucial factor affecting erythropoiesis, has been reported to be a protective molecule regulating the process of myocardial ischemia and relevant damage. No study has as yet reported the relationship between RDW and endogenous EPO in CAD patients. This cross-sectional study aimed to establish the association between endogenous EPO levels and increases in RDW in CAD patients. Patients and methods Two hundred participants who underwent coronary arteriography were recruited from July 2015 to October 2015. The participants were divided into CAD and non-CAD groups on the basis of angiography diagnosis. Demographic data were obtained through personal interviews and general clinical methods. Results RDW and EPO levels in the CAD group were higher than those in the non-CAD group. The correlation between RDW and EPO levels was statistically significant among CAD patients (r=0.411, P
DOI
10.1097/MCA.0000000000000554
Access Rights
subscription content
Comments
Li, Y., Li, M., Teng, Y., Zhang, C., Liu, Q., & Hou, H. (2018). The association between red cell distribution width, erythropoietin levels, and coronary artery disease. Coronary artery disease, 29(1), 74-80. Available here.