Associations of dietary protein and fiber intake with brain and blood amyloid-β
Authors
Warnakulasuriya M. Fernando, Edith Cowan UniversityFollow
Stephanie R. Rainey-Smith, Edith Cowan UniversityFollow
Samantha L. Gardener, Edith Cowan UniversityFollow
Victor L. Villemagne
Samantha C. Burnham
Macaulay S. Lance
Belinda M. Brown
Veer Gupta, Edith Cowan UniversityFollow
Hamid R. Sohrabi, Edith Cowan UniversityFollow
Michael Weinborn
Kevin Taddei, Edith Cowan UniversityFollow
Simon M. LawsFollow
Kathryn Goozee
David Ames
Christopher Fowler
Paul Maruff
Colin L. Masters
Olivier Salvado
Christopher Rowe
Ralph N. Martins, Edith Cowan UniversityFollow
Document Type
Journal Article
Publication Title
Journal of Alzheimer's Disease
Publisher
I O S Press
School
Centre of Excellence for Alzheimer's Disease Research and Care / School of Medical and Health Sciences
RAS ID
27387
Abstract
Accumulating evidence suggests a diet high in protein and fiber may confer some protection against Alzheimer's disease (AD). However, no human studies to-date have assessed the relationship between protein and fiber intake, and plasma and brain amyloid-β (Aβ). Consequently, this cross-sectional study, investigated the association of self-reported dietary intakes of protein and fiber, with plasma and brain Aβ burden (n = 541, and n = 162 respectively), in a well-characterized cohort of cognitively normal older adults, drawn from the larger Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. We observed 12.59 and 8.43 higher odds of 'high' brain Aβ burden (PiB PET SUVR≥1.5) if protein intake fell in the lowest and middle tertile, respectively, compared to the highest tertile (p = 0.008; p = 0.013). Thus, in this cohort, the more protein consumed, the less likelihood of 'high' Aβ burden in the brain. No other significant associations were observed. The results of this study highlight the potentially protective impact of high dietary protein intake on brain Aβ burden in older adults, before objective memory decline is apparent. While longitudinal validation is required, these findings may assist in the development of dietary approaches aimed at preventing or delaying AD onset.
DOI
10.3233/JAD-170742
Access Rights
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Comments
Fernando, W. M. A. D., Rainey-Smith, S. R., Gardener, S. L., Villemagne, V. L., Burnham, S. C., Macaulay, S. L., ... & Taddei, K. (2018). Associations of dietary protein and fiber intake with brain and blood Amyloid-β. Journal of Alzheimer's Disease, 61(4), 1589-1598. Available here.