Metabolic syndrome among schizophrenic patients: A comparative cross-sectional study in the middle belt of Ghana

Authors

Angela Owusu-Ansah
Anto Berko Panyin
Christian Obirikorang
Christian Agyare
Emmanuel Acheampong, Edith Cowan UniversityFollow
Simon Kwofie
Enoch Odame Anto, Edith Cowan UniversityFollow
Emmanuella Nsenbah Batu

Document Type

Journal Article

Publication Title

Schizophrenia Research and Treatment

School

School of Medical and Health Sciences

RAS ID

29475

Comments

Owusu–Ansah, A., Berko Panyin, A., Obirikorang, C., Agyare, C., Acheampong, E., Kwofie, S., ... & Nsenbah Batu, E. (2018). Metabolic Syndrome among Schizophrenic Patients: A Comparative Cross-Sectional Study in the Middle Belt of Ghana. Schizophrenia research and treatment, 2018, 9 pages. Available here

Abstract

The study determined the prevalence ofMetS in patients with schizophrenia at the Psychiatric Unit of the Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana. This comparative cross-sectional study recruited 348 schizophrenic patients comprising 236 antipsychotic-treated and 112 newly diagnosed treatment-na¨ıve patients. The MetS prevalence was assessed based on World Health Organization (WHO), International Diabetes Federation (IDF), and the National Cholesterol Education Programme, Adult Treatment Panel III (NCEP ATP III) criteria. The overall prevalence of MetS was 14.1%, 20.4%, and 23.6% using NCEP ATP III, WHO, and IDF criteria, respectively, compared to 7.8%, 3.9%, and 2.2% reported in the generalGhanaian population.The prevalence was significantly higher among treated psychiatric patients compared to treatment-na¨ıve group based on NCEP ATP III (17.8% versus 6.2%; p = 0.0001), WHO (26.2% versus 8.0%; p < 0.0001), and IDF (30.3% versus 10.0%; p < 0.0001). MetS was prevalent among patients on atypical antipsychotics compared to typical antipsychotics irrespective of the criteria used (i.e., 17.1% versus 11.1% for NCEP ATP III; 29.5% versus 25.9% for WHO; and 44.3% versus 18.5% for IDF). Using logistic regression model, obesity, raised fasting blood sugar, raised total cholesterol, and decreased high density lipoprotein were observed to be significant predictors of MetS (p<0.05).The study found high prevalence of MetS in Ghanaians with schizophrenia and higher prevalence rate of MetS associated with monotherapy. Regular monitoring of cardiometabolic parameters should be an important therapeutic objective in the management of these patients.

DOI

10.1155/2018/6542983

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.