The relationship between BPAQ-derived physical activity and bone density of middle-aged and older men

Abstract

Summary: The bone-specific physical activity questionnaire (BPAQ) accounts for activities that affect bone but has not been used in studies with older adults. Relationships exist between the BPAQ-derived physical activity and bone density in healthy middle-aged and older men but not men with prostate cancer. Disease-related treatments detrimental to bone should be considered when administering the BPAQ.Introduction: The bone-specific physical activity questionnaire (BPAQ) was developed to account for bone-specific loading. In this retrospective study, we examined the relationship between BPAQ-derived physical activity and bone mineral density (BMD) in middle-aged and older men with and without prostate cancer.Methods: Two groups, 36 healthy men and 69 men with prostate cancer receiving androgen suppression therapy (AST), completed the BPAQ and had whole body, total hip, femoral (FN) and lumbar spine BMD assessed by dual-energy X-ray absorptiometry.Results: Past (pBPAQ), current (cBPAQ) and total BPAQ (tBPAQ) scores for the healthy men were related to FN BMD (pBPAQ r = 0.36, p = 0.030; cBPAQ rs = 0.35, p = 0.034; tBPAQ r = 0.41, p = 0.014), and pBPAQ and tBPAQ were related to total hip (rs = 0.35, p = 0.035 and rs = 0.36, p = 0.029, respectively) and whole body BMD (rs = 0.44, p = 0.007 and rs = 0.45, p = 0.006, respectively). In men with prostate cancer, the BPAQ was not significantly associated with BMD. In stepwise regression analyses, body mass and tBPAQ predicted 30 % of the variance in total hip BMD (p = 0.003), cBPAQ predicted 14 % of the variance in FN BMD (p = 0.002), and body mass, age and tBPAQ predicted 47 % of the variance in whole body BMD (p < 0.001) in healthy men. In men with prostate cancer, the BPAQ was not an independent predictor of BMD.Conclusions: Although BPAQ-derived estimates of physical activity are related to bone status in healthy middle-aged and older men, the adverse effect of AST on bone appears to obscure this relationship in men with prostate cancer.

Keywords

Bone mass, BPAQ, Osteoporosis, Physical activity, Prostate cancer, androgen, adult, aged, androgen suppression therapy, androgen therapy, Article, body mass, bone density, bone specific physical activity questionnaire, clinical article, controlled study, dual energy X ray absorptiometry, human, lumbar spine, male, middle aged, physical activity, prostate cancer, questionnaire, retrospective study

Document Type

Journal Article

Date of Publication

1-1-2014

Faculty

Faculty of Health, Engineering and Science

Publisher

Springer Verlag

School

School of Exercise and Health Sciences

RAS ID

18921

Comments

Bolam K.A., Beck B.R., Adlard K.N., Skinner T.L., Cormie P., Galvao D.A., Spry N., Newton R.U., Taaffe D.R. (2014). The relationship between BPAQ-derived physical activity and bone density of middle-aged and older men. Osteoporosis International, 25(11), 2663-2668. Available here

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Link to publisher version (DOI)

10.1007/s00198-014-2797-z