The changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia

Authors

Di Liu
Xi Chu
Hao Wang, Edith Cowan UniversityFollow
Jing Dong
Si-Qi Ge, Edith Cowan University
Zhong-Yao Zhao
Hong-Li Peng
Ming Sun
Li-Juan Wu
Man-Shu Song
Xiu-Hua Guo
Qun Meng
You-Xin Wang
Gordan Lauc
Wei Wang, Edith Cowan UniversityFollow

Document Type

Journal Article

Publication Title

Journal of Translational Medicine

Publisher

BioMed Central Ltd

School

School of Medical and Health Sciences

RAS ID

27256

Comments

Liu, D., Chu, X., Wang, H., Dong, J., Ge, S. Q., Zhao, Z. Y., ... & Guo, X. H. (2018). The changes of immunoglobulin GN-glycosylation in blood lipids and dyslipidaemia. Journal of translational medicine, 16(1), 235. Available here

Abstract

Background

Alternative N-glycosylation has significant structural and functional consequences on immunoglobulin G (IgG) and can affect immune responses, acting as a switch between pro- and anti-inflammatory IgG functionality. Studies have demonstrated that IgG N-glycosylation is associated with ageing, body mass index, type 2 diabetes and hypertension.

Methods

Herein, we have demonstrated patterns of IgG glycosylation that are associated with blood lipids in a cross-sectional study including 598 Han Chinese aged 20–68 years. The IgG glycome composition was analysed by ultra-performance liquid chromatography.

Results

Blood lipids were positively correlated with glycan peak GP6, whereas they were negatively correlated with GP18 (P < 0.05/57). The canonical correlation analysis indicated that initial N-glycan structures, including GP4, GP6, GP9-12, GP14, GP17, GP18 and GP23, were significantly correlated with blood lipids, including total cholesterol, total triglycerides (TG) and low-density lipoprotein (r = 0.390, P < 0.001). IgG glycans patterns were able to distinguish patients with dyslipidaemia from the controls, with an area under the curve of 0.692 (95% confidence interval 0.644–0.740).

Conclusions

Our findings indicated that a possible association between blood lipids and the observed loss of galactose and sialic acid, as well as the addition of bisecting GlcNAcs, which might be related to the chronic inflammation accompanying with the development and procession of dyslipidaemia.

DOI

10.1186/s12967-018-1616-2

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.