Abstract

OBJECTIVE: Compare vitamin D levels in opioid dependence and control population and adjust for relevant confounding effects. Nuclear hormone receptors (including the vitamin D receptor) have been shown to be key transducers and regulators of intracellular metabolism and comprise an important site of pathophysiological immune and metabolic dysregulation potentially contributing towards pro-ageing changes observed in opioid-dependent patients (ODPs).

DESIGN: Longitudinal prospective comparing ODPs with general medical controls (GMCs).

SETTING: Primary care.

PARTICIPANTS: Prospective review comparing 1168 ODP (72.5% men) and 415 GMC (51.6% men, p

INTERVENTIONS: Nil. Observational study only.

PRIMARY AND SECONDARY OUTCOMES: Serum vitamin D levels and relevant biochemical parameters.

RESULTS: Vitamin D levels were higher in the ODP (70.35±1.16 and 57.06±1.81 nmol/L, p

CONCLUSION: Vitamin D was higher in ODP in both sexes in bivariate, cross-sectional, case

RAS ID

29474

Document Type

Journal Article

Date of Publication

1-13-2018

ISSN

2044-6055

Volume

8

Issue

1

PubMed ID

29331964

School

School of Arts and Humanities

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Publisher

BMJ Publishing Group

Comments

Reece, A. S., & Hulse, G. K. (2018). What are the characteristics of vitamin D metabolism in opioid dependence? An exploratory longitudinal study in Australian primary care. BMJ open, 8(1), e016806. Available here

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Link to publisher version (DOI)

10.1136/bmjopen-2017-016806