Abstract

OBJECTIVE: Compare vitamin D levels in opioid dependence and control population and adjust for relevant confounding effects. Nuclear hormone receptors (including the vitamin D receptor) have been shown to be key transducers and regulators of intracellular metabolism and comprise an important site of pathophysiological immune and metabolic dysregulation potentially contributing towards pro-ageing changes observed in opioid-dependent patients (ODPs).

DESIGN: Longitudinal prospective comparing ODPs with general medical controls (GMCs).

SETTING: Primary care.

PARTICIPANTS: Prospective review comparing 1168 ODP (72.5% men) and 415 GMC (51.6% men, p

INTERVENTIONS: Nil. Observational study only.

PRIMARY AND SECONDARY OUTCOMES: Serum vitamin D levels and relevant biochemical parameters.

RESULTS: Vitamin D levels were higher in the ODP (70.35±1.16 and 57.06±1.81 nmol/L, p

CONCLUSION: Vitamin D was higher in ODP in both sexes in bivariate, cross-sectional, case

Document Type

Journal Article

Date of Publication

1-13-2018

ISSN

2044-6055

Volume

8

Issue

1

PubMed ID

29331964

Publication Title

BMJ Open

Publisher

BMJ Publishing Group

School

School of Arts and Humanities

RAS ID

29474

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Comments

Reece, A. S., & Hulse, G. K. (2018). What are the characteristics of vitamin D metabolism in opioid dependence? An exploratory longitudinal study in Australian primary care. BMJ open, 8(1), e016806. Available here

First Page

016806

Last Page

016806

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Link to publisher version (DOI)

10.1136/bmjopen-2017-016806