Document Type

Journal Article

Publication Title

BMJ Open

Medical Subject Headings

Adult; Age Factors; Alanine Transaminase; Analgesics, Opioid; Australia; Case-Control Studies; Cross-Sectional Studies; Female; Humans; Longitudinal Studies; Male; Opioid-Related Disorders; Primary Health Care; Prospective Studies; Vitamin D; Vitamins

ISSN

2044-6055

Volume

8

Issue

1

First Page

016806

Last Page

016806

PubMed ID

29331964

Publisher

BMJ Publishing Group

School

School of Arts and Humanities

Comments

Originally published as : Reece, A. S., & Hulse, G. K. (2018). What are the characteristics of vitamin D metabolism in opioid dependence? An exploratory longitudinal study in Australian primary care. BMJ open, 8(1), e016806. Article can be found here

Abstract

OBJECTIVE: Compare vitamin D levels in opioid dependence and control population and adjust for relevant confounding effects. Nuclear hormone receptors (including the vitamin D receptor) have been shown to be key transducers and regulators of intracellular metabolism and comprise an important site of pathophysiological immune and metabolic dysregulation potentially contributing towards pro-ageing changes observed in opioid-dependent patients (ODPs).

DESIGN: Longitudinal prospective comparing ODPs with general medical controls (GMCs).

SETTING: Primary care.

PARTICIPANTS: Prospective review comparing 1168 ODP (72.5% men) and 415 GMC (51.6% men, p

INTERVENTIONS: Nil. Observational study only.

PRIMARY AND SECONDARY OUTCOMES: Serum vitamin D levels and relevant biochemical parameters.

RESULTS: Vitamin D levels were higher in the ODP (70.35±1.16 and 57.06±1.81 nmol/L, p

CONCLUSION: Vitamin D was higher in ODP in both sexes in bivariate, cross-sectional, case

DOI

10.1136/bmjopen-2017-016806

Access Rights

free_to_read

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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