What are the characteristics of vitamin D metabolism in opioid dependence? An exploratory longitudinal study in Australian primary care
Medical Subject Headings
Adult, Age Factors, Alanine Transaminase, Analgesics, Opioid, Australia, Case-Control Studies, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Male, Opioid-Related Disorders, Primary Health Care, Prospective Studies, Vitamin D, Vitamins
BMJ Publishing Group
School of Arts and Humanities
OBJECTIVE: Compare vitamin D levels in opioid dependence and control population and adjust for relevant confounding effects. Nuclear hormone receptors (including the vitamin D receptor) have been shown to be key transducers and regulators of intracellular metabolism and comprise an important site of pathophysiological immune and metabolic dysregulation potentially contributing towards pro-ageing changes observed in opioid-dependent patients (ODPs).
DESIGN: Longitudinal prospective comparing ODPs with general medical controls (GMCs).
SETTING: Primary care.
PARTICIPANTS: Prospective review comparing 1168 ODP (72.5% men) and 415 GMC (51.6% men, p
INTERVENTIONS: Nil. Observational study only.
PRIMARY AND SECONDARY OUTCOMES: Serum vitamin D levels and relevant biochemical parameters.
RESULTS: Vitamin D levels were higher in the ODP (70.35±1.16 and 57.06±1.81 nmol/L, p
CONCLUSION: Vitamin D was higher in ODP in both sexes in bivariate, cross-sectional, case
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Reece, A. S., & Hulse, G. K. (2018). What are the characteristics of vitamin D metabolism in opioid dependence? An exploratory longitudinal study in Australian primary care. BMJ open, 8(1), e016806. Available here