Authors/Creators
Haibin Li
Anxin Wang
Wei Feng
Deqiang Zheng
Qi Gao
Lixin Tao
Jin Guo
Xiaonan Wang
Xia Li
Wei Wang, Edith Cowan UniversityFollow
Xiuhua Guo
Abstract
The longitudinal association between glycated hemoglobin (HbA1c) and different courses of depressive symptoms is understudied. This study aimed to identify different trajectories of depressive symptoms and investigate the relation of HbA1c with the risk of increasing and high-stable depressive symptoms. In the China Health and Retirement Longitudinal Study, depressive symptoms were measured using the 10-item Center for Epidemiological Studies-Depression scale in three visits (years: 2011, 2013 and 2015) among 9804 participants (mean age 60.0 ± 9.0 years). Group-based trajectory modeling was used to identify trajectories of depressive symptoms. HbA1c was measured at baseline and categorized five groups according to the respective quintile. Multinomial logistic regression was fitted to examine this relationship. Four distinct trajectories of depressive symptoms were identified: low symptoms (n=6401, 65.29%); decreasing symptoms (n=1362, 13.89%); increasing symptoms (n=1452, 14.81%); and high symptoms (n=1452, 14.81%). Adjusting for demographic, health-related, and cognitive factors, the risk ratio (95% confidence interval) pertaining to the highest HbA1c (Quintile 5) for decreasing, increasing, and high symptoms of depression versus low symptoms was 1.01 (0.82-1.25), 1.12 (0.92-1.36), and 1.39 (1.04-1.86) compared with the lowest HbA1c (Quintile 1), respectively. We observed a J-shaped relationship between HbA1c and high depressive symptoms, with the lowest risk at a HbA1c concentration of 5.0%. In summary, in this large population-based cohort, high levels of glycated hemoglobin concentrations were associated with a higher risk of increasing and high-stable symptoms of depression.
RAS ID
31327
Document Type
Journal Article
Date of Publication
4-1-2019
ISSN
2152-5250
Volume
10
Issue
2
Funding Information
Funding information available at: https://doi.org/10.14336/AD.2018.0410
PubMed ID
31011476
School
School of Medical and Health Sciences
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Publisher
International Society on Aging and Disease
Recommended Citation
Li, H., Wang, A., Feng, W., Zheng, D., Gao, Q., Tao, L., Guo, J., Wang, X., Li, X., Wang, W., & Guo, X. (2019). Prospective study of glycated hemoglobin and trajectories of depressive symptoms: The China Health and Retirement Longitudinal Study. DOI: https://doi.org/10.14336/AD.2018.0410
Comments
Li, H., Wang, A., Feng, W., Zheng, D., Gao, Q., Tao, L., ... Guo, X. (2019). Prospective study of glycated hemoglobin and trajectories of depressive symptoms: the China health and retirement longitudinal study. Aging and Disease, 10(2), 249-257. Available here