Document Type
Journal Article
Publication Title
Journal of Renal and Hepatic Disorders
Publisher
Codon Publications
School
School of Medical and Health Sciences
RAS ID
26761
Abstract
Chronic liver diseases (CLDs) are increasing in prevalence and their end-stage complications, namely, cirrhosis, liver failure and hepatocellular carcinoma represent major global challenges. The most common initiators of progressive CLD are viral hepatitis and long-term alcohol abuse as well as steatosis and steatohepatitis. Irrespective of the underlying aetiology, a common feature of CLD is the formation of hepatic ductular reactions, involving the proliferation of liver progenitor cells (LPCs) and their signalling to fibrosis-driving hepatic stellate cells. The Wnt/β-catenin pathway has been found to regulate development, stemness and differentiation, and alterations in its activity have been associated with tumour development. Recent data highlight the role of Wnt/β-catenin signalling in hepatic metabolism, steatosis and cancer, and suggest targeting of this pathway as a promising molecular strategy to potentially inhibit CLD progression and hepatocarcinogenesis.
DOI
10.15586/jrenhep.2018.29
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Shirolkar, G. D., Pasic, S., Gogoi-Tiwari, J., Bhat, M. K., Olynyk, J. K., Dharmarajan, A., & Tirnitz-Parker, J. E. (2018). Wnt/β-Catenin Signalling during Liver Metabolism, Chronic Liver Disease and Hepatocarcinogenesis. Journal of Renal and Hepatic Disorders, 2(1), 1-9. Available here