Document Type
Journal Article
Publication Title
OMICS : A Journal of Integrative Biology
ISSN
1557-8100
Volume
22
Issue
11
First Page
679
Last Page
695
PubMed ID
30457467
Publisher
Mary Ann Libert, Inc. Publishers
School
School of Medical and Health Sciences / School of Science
RAS ID
27769
Grant Number
NHMRC Number : 1112767
Abstract
Joseph John Thomson discovered and proved the existence of electrons through a series of experiments. His work earned him a Nobel Prize in 1906 and initiated the era of mass spectrometry (MS). In the intervening time, other researchers have also been awarded the Nobel Prize for significant advances in MS technology. The development of soft ionization techniques was central to the application of MS to large biological molecules and led to an unprecedented interest in the study of biomolecules such as proteins (proteomics), metabolites (metabolomics), carbohydrates (glycomics), and lipids (lipidomics), allowing a better understanding of the molecular underpinnings of health and disease. The interest in large molecules drove improvements in MS resolution and now the challenge is in data deconvolution, intelligent exploitation of heterogeneous data, and interpretation, all of which can be ameliorated with a proposed IMass technology. We define IMass as a combination of MS and artificial intelligence, with each performing a specific role. IMass will offer advantages such as improving speed, sensitivity, and analyses of large data that are presently not possible with MS alone. In this study, we present an overview of the MS considering historical perspectives and applications, challenges, as well as insightful highlights of IMass.
DOI
10.1089/omi.2018.0162
Comments
This is an Author's Accepted Manuscript of: Ma, Q., Adua, E., Boyce, M. C., Li, X., Ji, G., & Wang, W. (2018). IIMass time: The future, in future!. OMICS: a Journal of Integrative Biology, 22(11), 679-695. Final publication is Available from Mary Ann Liebert, Inc., publishers at: https://doi.org/10.1089/omi.2018.0162