Enhanced availability of serotonin increases activation of unfatigued muscle but exacerbates central fatigue during prolonged sustained contractions
Abstract
KEY POINTS: Animal preparations have revealed that moderate synaptic release of serotonin (5-HT) onto motoneurones enhances motor activity via activation of 5-HT
ABSTRACT: Brief stimulation of the raphe-spinal pathway in the turtle spinal cord releases serotonin (5-HT) onto motoneurones to enhance excitability. However, intense release of 5-HT via prolonged stimulation results in 5-HT spillover to the motoneurone axon initial segment to activate inhibitory 5-HT
Document Type
Journal Article
Date of Publication
1-1-2019
ISSN
1469-7793
Volume
597
Issue
1
PubMed ID
30328105
Publication Title
The Journal of Physiology
Publisher
Cambridge University Press
School
School of Medical and Health Sciences
RAS ID
29842
Copyright
subscription content
First Page
319
Last Page
332
Comments
Kavanagh, J. J., McFarland, A. J., & Taylor, J. L. (2019). Enhanced availability of serotonin increases activation of unfatigued muscle but exacerbates central fatigue during prolonged sustained contractions. The Journal of Physiology, 597(1), 319-332.
Available here.