Enhanced availability of serotonin increases activation of unfatigued muscle but exacerbates central fatigue during prolonged sustained contractions
Abstract
KEY POINTS: Animal preparations have revealed that moderate synaptic release of serotonin (5-HT) onto motoneurones enhances motor activity via activation of 5-HT
ABSTRACT: Brief stimulation of the raphe-spinal pathway in the turtle spinal cord releases serotonin (5-HT) onto motoneurones to enhance excitability. However, intense release of 5-HT via prolonged stimulation results in 5-HT spillover to the motoneurone axon initial segment to activate inhibitory 5-HT
Document Type
Journal Article
ISSN
1469-7793
Volume
597
Issue
1
PubMed ID
30328105
School
School of Medical and Health Sciences
RAS ID
29842
Copyright
subscription content
Publisher
Cambridge University Press
Comments
Kavanagh, J. J., McFarland, A. J., & Taylor, J. L. (2019). Enhanced availability of serotonin increases activation of unfatigued muscle but exacerbates central fatigue during prolonged sustained contractions. The Journal of Physiology, 597(1), 319-332.
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