Human versus non-human sex steroid use in hormone replacement therapies part 1: Preclinical data
Abstract
Prior to 2002, hormone replacement therapy (HRT) was considered to be an important component of postmenopausal healthcare. This was based on a plethora of basic, epidemiological and clinical studies demonstrating the health benefits of supplementation with human sex steroids. However, adverse findings from the Women's Health Initiative (WHI) studies that examined the 2 major forms of HRT in use in the US at that time - Premarin (conjugated equine estrogens; CEE) and Prempro (CEE + medroxyprogesterone acetate; MPA), cast a shadow over the use of any form of HRT. Here we review the biochemical and physiological differences between the non-human WHI study hormones - CEE and MPA, and their respective human counterparts 17β-estradiol (E
Document Type
Journal Article
ISSN
1872-8057
Volume
480
PubMed ID
30308266
School
School of Medical and Health Sciences
RAS ID
31287
Copyright
subscription content
Publisher
North Holland Publishing
Comments
Atwood, C. S., & Ekstein, S. F. (2019). Human versus non-human sex steroid use in hormone replacement therapies part 1: Preclinical data. Molecular and Cellular Endocrinology 480, 12-35.
Available here.