Modulating functional connectivity with non-invasive brain stimulation for the investigation and alleviation of age-associated declines in response inhibition: A narrative review
Authors
Jane Tan
Kartik K. Iyer
Alexander D. Tang
Asif Jamil
Ralph N. Martins, Edith Cowan UniversityFollow
Hamid R. Sohrabi, Edith Cowan UniversityFollow
Michael A. Nitsche
Mark R. Hinder
Hakuei Fujiyama
Document Type
Journal Article
Publication Title
NeuroImage
ISSN
1095-9572
Volume
185
First Page
490
Last Page
512
PubMed ID
30342977
Publisher
Academic Press
School
School of Medical and Health Sciences / Centre of Excellence for Alzheimer’s Disease Research and Care
RAS ID
28910
Grant Number
NHMRC : 1046267
Grant Link
http://purl.org/au-research/grants/nhmrc/1046267
Abstract
Response inhibition, the ability to withhold a dominant and prepotent response following a change in circumstance or sensory stimuli, declines with advancing age. While non-invasive brain stimulation (NiBS) has shown promise in alleviating some cognitive and motor functions in healthy older individuals, NiBS research focusing on response inhibition has mostly been conducted on younger adults. These extant studies have primarily focused on modulating the activity of distinct neural regions known to be critical for response inhibition, including the right inferior frontal gyrus (rIFG) and the pre-supplementary motor area (pre-SMA). However, given that changes in structural and functional connectivity have been associated with healthy aging, this review proposes that NiBS protocols aimed at modulating the functional connectivity between the rIFG and pre-SMA may be the most efficacious approach to investigate-and perhaps even alleviate-age-related deficits in inhibitory control.
DOI
10.1016/j.neuroimage.2018.10.044
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Comments
Tan, J., Iyer, K. K., Tang, A. D., Jamil, A., Martins, R. N., Sohrabi, H. R., ... & Fujiyama, H. (2019). Modulating functional connectivity with non-invasive brain stimulation for the investigation and alleviation of age-associated declines in response inhibition: A narrative review. NeuroImage, 185, 490-512.
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