Assessment of diets containing curcumin, epigallocatechin-3-gallate, docosahexaenoic acid and α-lipoic acid on amyloid load and inflammation in a male transgenic mouse model of Alzheimer's disease: Are combinations more effective?
Authors/Creators
Matthew J. Sharman
Erika Gyengesi
Huazheng Liang
Pratishtha Chatterjee, Edith Cowan UniversityFollow
Tim Karl
Qiao-Xin Li
Markus R Wenk
Barry Halliwell
Ralph N. Martins, Edith Cowan UniversityFollow
Gerald Münch
Abstract
Increasingly, evidence is accumulating pointing at a protective role of a healthy diet at decreasing the risk of Alzheimer's disease. To test the effectiveness of nutritional components, the following food-derived compounds: curcumin alone (curcumin), curcumin combined with (-)epigallocatechin-3-gallate (EGCG), docosahexaenoic acid (DHA) and α-lipoic acid (ALA) (curcumin + EDA), or a combination of EGCG, DHA and ALA (EDA) were assessed in male Tg2576 transgenic mice on amyloid plaque load, amyloid levels (Aβ40/Aβ42, but not oligomers due to tissue limitations), microglial activation and memory using the contextual and cued fear conditioning test. The combination diet EDA, resulted in the strongest reduction of amyloid plaque load in both the cortical (p < .0001) and hippocampal (p < .0001) areas of the Tg2576 mouse brain, along with lower Aβ
RAS ID
28832
Document Type
Journal Article
Date of Publication
1-2-2019
ISSN
1095-953X
Volume
124
PubMed ID
30610916
School
School of Medical and Health Sciences / Centre of Excellence for Alzheimer's Disease Research and Care
Grant Number
NHMRC Number : 480102
Copyright
subscription content
Publisher
Academic Press
Recommended Citation
Sharman, M. J., Gyengesi, E., Liang, H., Chatterjee, P., Karl, T., Li, Q., Wenk, M., Halliwell, B., Martins, R. N., & Münch, G. (2019). Assessment of diets containing curcumin, epigallocatechin-3-gallate, docosahexaenoic acid and α-lipoic acid on amyloid load and inflammation in a male transgenic mouse model of Alzheimer's disease: Are combinations more effective?. DOI: https://doi.org/10.1016/j.nbd.2018.11.026
Comments
Sharman, M. J., Gyengesi, E., Liang, H., Chatterjee, P., Karl, T., Li, Q. -., . . . Münch, G. (2019). Assessment of diets containing curcumin, epigallocatechin-3-gallate, docosahexaenoic acid and α-lipoic acid on amyloid load and inflammation in a male transgenic mouse model of alzheimer's disease: Are combinations more effective? Neurobiology of Disease, 124, 505-519. Available here