Title

Assessment of diets containing curcumin, epigallocatechin-3-gallate, docosahexaenoic acid and α-lipoic acid on amyloid load and inflammation in a male transgenic mouse model of Alzheimer's disease: Are combinations more effective?

Document Type

Journal Article

Publication Title

Neurobiology of disease

ISSN

1095-953X

Volume

124

First Page

505

Last Page

519

PubMed ID

30610916

Publisher

Academic Press

School

School of Medical and Health Sciences/ Centre of Excellence for Alzheimer's Disease Research and Care

Comments

Originally published as: Sharman, M. J., Gyengesi, E., Liang, H., Chatterjee, P., Karl, T., Li, Q. -., . . . Münch, G. (2019). Assessment of diets containing curcumin, epigallocatechin-3-gallate, docosahexaenoic acid and α-lipoic acid on amyloid load and inflammation in a male transgenic mouse model of alzheimer's disease: Are combinations more effective? Neurobiology of Disease, 124, 505-519. Original article available here

Abstract

Increasingly, evidence is accumulating pointing at a protective role of a healthy diet at decreasing the risk of Alzheimer's disease. To test the effectiveness of nutritional components, the following food-derived compounds: curcumin alone (curcumin), curcumin combined with (-)epigallocatechin-3-gallate (EGCG), docosahexaenoic acid (DHA) and α-lipoic acid (ALA) (curcumin + EDA), or a combination of EGCG, DHA and ALA (EDA) were assessed in male Tg2576 transgenic mice on amyloid plaque load, amyloid levels (Aβ40/Aβ42, but not oligomers due to tissue limitations), microglial activation and memory using the contextual and cued fear conditioning test. The combination diet EDA, resulted in the strongest reduction of amyloid plaque load in both the cortical (p < .0001) and hippocampal (p < .0001) areas of the Tg2576 mouse brain, along with lower Aβ

DOI

10.1016/j.nbd.2018.11.026

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