Document Type
Journal Article
Publication Title
The British Journal of Nutrition
ISSN
1475-2662
Volume
121
Issue
3
First Page
322
Last Page
329
PubMed ID
30419974
Publisher
Cambridge University Press
School
School of Medical and Health Sciences
RAS ID
27682
Abstract
The Paleolithic diet excludes two major sources of fibre, grains and legumes. However, it is not known whether this results in changes to resistant starch (RS) consumption. Serum trimethylamine-N-oxide (TMAO) is produced mainly from colonic fermentation and hepatic conversion of animal protein and is implicated in CVD, but changes in RS intake may alter concentrations. We aimed to determine whether intake of RS and serum concentrations of TMAO varied in response to either the Paleolithic or the Australian Guide to Healthy Eating (AGHE) diets and whether this was related to changes in food group consumption. A total of thirty-nine women (mean age 47 (sd 13) years, BMI 27 (sd 4) kg/m2) were randomised to AGHE (n 17) or Paleolithic diets (n 22) for 4 weeks. Serum TMAO concentrations were measured using liquid chromatography-MS; food groups, fibre and RS intake were estimated from weighed food records. The change in TMAO concentrations between groups (Paleolithic 3·39 μm v. AGHE 1·19 μm, P = 0·654) did not reach significance despite greater red meat and egg consumption in the Paleolithic group (0·65 serves/d; 95 % CI 0·2, 1·1; P
DOI
10.1017/S000711451800329X
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Genoni, A., Lo, J., Lyons-Wall, P., Boyce, M. C., Christophersen, C. T., Bird, A., & Devine, A. (2019). A Paleolithic diet lowers resistant starch intake but does not affect serum trimethylamine-N-oxide concentrations in healthy women. British Journal of Nutrition, 121(3), 322-329. Available here