Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans

Abstract

Background: Increased body fat may be associated with an increased risk of developing an underlying pro-inflammatory state, thus leading to greater risk of developing certain chronic conditions. Immunoglobulin G has the ability to exert both anti- and pro-inflammatory effects, and the N-glycosylation of the fragment crystallisable portion is involved in mediating this process. Body mass index, a rudimentary yet gold standard indication for body fat, has been shown to be associated with agalactosylated immunoglobulin G N-glycans. Aim: We aimed to determine the association between increased body fat and the immunoglobulin G glycosylation features, comparing body mass index to other measures of body fat distribution. Methods: We investigated a sample of 637 community-based 45–69 year olds, with mixed phenotypes, residing in Busselton, Western Australia. Body mass index and the waist-to-hip and waist-to-height ratios were calculated using anthropometry, while dual-energy x-ray absorptiometry was performed to gain an accurate measure of total and area specific body fat. Serum immunoglobulin GN-glycans were analysed by ultra-performance liquid chromatography. Results: Twenty-two N-glycan peaks were found to be associated with at least one of the fat measures. While the previous association of body mass index to agalactosylated immunoglobulin G was replicated, measures of central adiposity explained the most variation in the immunoglobulin G glycome. Conclusion: Central adiposity is associated with an increased pro-inflammatory fraction of immunoglobulin G, suggesting that the android/gynoid ratio or waist-to-height ratio instead be considered when controlling for adiposity in immunoglobulin G glycome biomarker studies. © 2018 Elsevier GmbH

RAS ID

28817

Document Type

Journal Article

Date of Publication

1-1-2019

PubMed ID

30446335

School

School of Medical and Health Sciences

Grant Number

NHMRC Number : 1112771

Copyright

free_to_read

Publisher

Elsevier GmbH

Comments

Russell, A. C., Kepka, A., Trbojević-Akmačić, I., Ugrina, I., Song, M., Hui, J., . . . Wang, W. (2019). Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans. Immunobiology, 224(1), 110-115. Available here

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Link to publisher version (DOI)

10.1016/j.imbio.2018.10.002