Klotho allele status is not associated with Aβ and APOE ε4–related cognitive decline in preclinical Alzheimer's disease
Authors/Creators
Tenielle Porter, Edith Cowan UniversityFollow
Samantha C. Burnham, Edith Cowan UniversityFollow
Lidija Milicic, Edith Cowan UniversityFollow
Greg Savage
Paul Maruff
Yen Ying Lim
David Ames
Colin L. Masters
Ralph N. Martins, Edith Cowan UniversityFollow
Stephanie Rainey-Smith, Edith Cowan UniversityFollow
Christopher C. Rowe
Olivier Salvado
David Groth
Giuseppe Verdile, Edith Cowan UniversityFollow
Victor L. Villemagne
Simon M. Laws, Edith Cowan UniversityFollow
Abstract
The longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously been associated with cognition and rates of cognitive decline. This study aimed to determine whether KL-VS associations with cognition were observable in preclinical Alzheimer's disease (AD). The study also aimed to determine whether there was a combined influence of KL-VS, neocortical amyloid-β (Aβ) burden, and carriage of the apolipoprotein E (APOE) ε4 allele on cognitive decline. This study involved 581 Aβ-imaged, cognitively normal older adults, enrolled in the Australian Imaging, Biomarkers and Lifestyle Study of Aging. Linear mixed effects models revealed no significant associations between KL-VS and cognitive decline independently or in combination with Aβ burden and APOE ε4 genotype. Overall, previous associations reported between KL-VS and cognitive decline are not observed at the preclinical stages of AD. Furthermore, the results do not support the hypothesis that KL-VS has a modifying effect on Aβ burden and APOE ε4–driven cognitive decline in preclinical AD. © 2019 Elsevier Inc.
Document Type
Journal Article
Date of Publication
1-1-2019
PubMed ID
30716541
Publication Title
Neurobiology of Aging
Publisher
Elsevier Inc
School
School of Medical and Health Sciences / Collaborative Genomics Group / Centre of Excellence for Alzheimer’s Disease Research and Care
RAS ID
28831
Copyright
subscription content
Comments
Porter, T., Burnham, S. C., Milicic, L., Savage, G., Maruff, P., Lim, Y. Y., . . . Laws, S. M. (2019). Klotho allele status is not associated with Aβ and APOE ε4–related cognitive decline in preclinical alzheimer's disease. Neurobiology of Aging, 76, 162-165. Available here