Klotho allele status is not associated with Aβ and APOE ε4–related cognitive decline in preclinical Alzheimer's disease

Document Type

Journal Article

Publication Title

Neurobiology of Aging

PubMed ID

30716541

Publisher

Elsevier Inc

School

School of Medical and Health Sciences / Collaborative Genomics Group / Centre of Excellence for Alzheimer’s Disease Research and Care

RAS ID

28831

Comments

Porter, T., Burnham, S. C., Milicic, L., Savage, G., Maruff, P., Lim, Y. Y., . . . Laws, S. M. (2019). Klotho allele status is not associated with Aβ and APOE ε4–related cognitive decline in preclinical alzheimer's disease. Neurobiology of Aging, 76, 162-165. Available here

Abstract

The longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously been associated with cognition and rates of cognitive decline. This study aimed to determine whether KL-VS associations with cognition were observable in preclinical Alzheimer's disease (AD). The study also aimed to determine whether there was a combined influence of KL-VS, neocortical amyloid-β (Aβ) burden, and carriage of the apolipoprotein E (APOE) ε4 allele on cognitive decline. This study involved 581 Aβ-imaged, cognitively normal older adults, enrolled in the Australian Imaging, Biomarkers and Lifestyle Study of Aging. Linear mixed effects models revealed no significant associations between KL-VS and cognitive decline independently or in combination with Aβ burden and APOE ε4 genotype. Overall, previous associations reported between KL-VS and cognitive decline are not observed at the preclinical stages of AD. Furthermore, the results do not support the hypothesis that KL-VS has a modifying effect on Aβ burden and APOE ε4–driven cognitive decline in preclinical AD. © 2019 Elsevier Inc.

DOI

10.1016/j.neurobiolaging.2018.12.014

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