Aberrant PD-1 ligand expression contributes to the myocardial inflammatory injury caused by Coxsackievirus B infection

Abstract

Coxsackievirus group B (CVB) is considered as one of the most common pathogens of human viral myocarditis. CVB-induced myocarditis is mainly characterized by the persistence of the virus infection and immune-mediated inflammatory injury. Costimulatory signals are crucial for the activation of adaptive immunity. Our data reveal that the CVB type 3 (CVB3) infection altered the expression profile of costimulatory molecules in host cells. CVB3 infection caused the decrease of PD-1 ligand expression, partially due to the cleavage of AU-rich element binding protein AUF1 by the viral protease 3C pro , leading to the exacerbated inflammatory injury of the myocardium. Moreover, systemic PD-L1 treatment, which augmented the apoptosis of proliferating lymphocytes, alleviated myocardial inflammatory injury. Our findings suggest that PD1-pathway can be a potential immunologic therapeutic target for CVB-induced myocarditis. © 2019 Elsevier B.V.

RAS ID

28490

Document Type

Journal Article

Date of Publication

1-1-2019

School

School of Medical and Health Sciences

Copyright

subscription content

Publisher

Elsevier BV

Comments

Wang, T., Chen, S., Wang, X., Huang, Y., Qiu, J., Fei, Y., . . . Zhong, Z. (2019). Aberrant PD-1 ligand expression contributes to the myocardial inflammatory injury caused by coxsackievirus B infection. Antiviral Research, 166, 1-10. Available here

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Link to publisher version (DOI)

10.1016/j.antiviral.2019.03.007