Aberrant PD-1 ligand expression contributes to the myocardial inflammatory injury caused by Coxsackievirus B infection

Document Type

Journal Article

Publication Title

Antiviral Research

Publisher

Elsevier BV

School

School of Medical and Health Sciences

RAS ID

28490

Comments

Wang, T., Chen, S., Wang, X., Huang, Y., Qiu, J., Fei, Y., . . . Zhong, Z. (2019). Aberrant PD-1 ligand expression contributes to the myocardial inflammatory injury caused by coxsackievirus B infection. Antiviral Research, 166, 1-10. Available here

Abstract

Coxsackievirus group B (CVB) is considered as one of the most common pathogens of human viral myocarditis. CVB-induced myocarditis is mainly characterized by the persistence of the virus infection and immune-mediated inflammatory injury. Costimulatory signals are crucial for the activation of adaptive immunity. Our data reveal that the CVB type 3 (CVB3) infection altered the expression profile of costimulatory molecules in host cells. CVB3 infection caused the decrease of PD-1 ligand expression, partially due to the cleavage of AU-rich element binding protein AUF1 by the viral protease 3C pro , leading to the exacerbated inflammatory injury of the myocardium. Moreover, systemic PD-L1 treatment, which augmented the apoptosis of proliferating lymphocytes, alleviated myocardial inflammatory injury. Our findings suggest that PD1-pathway can be a potential immunologic therapeutic target for CVB-induced myocarditis. © 2019 Elsevier B.V.

DOI

10.1016/j.antiviral.2019.03.007

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Link to publisher version (DOI)

10.1016/j.antiviral.2019.03.007