Exercise mode specificity for preserving spine and hip bone mineral density in prostate cancer patients
Authors
Robert U. Newton, Edith Cowan UniversityFollow
Daniel A. Galvao, Edith Cowan UniversityFollow
Nigel Spry, Edith Cowan UniversityFollow
David Joseph, Edith Cowan UniversityFollow
Suzanne K. Chambers, Edith Cowan UniversityFollow
Robert A. Gardiner, Edith Cowan UniversityFollow
Brad A. Wall
Kate A. Bolam
Dennis R. Taaffe, Edith Cowan UniversityFollow
Author Identifier
Robert U Newton
https://orcid.org/0000-0003-0302-6129
Daniel A Galvao
https://orcid.org/0000-0002-8209-2281
Nigel Spry
https://orcid.org/0000-0001-8659-5065
Suzanne K Chambers
https://orcid.org/0000-0003-2369-6111
Dennis Taaffe
Document Type
Journal Article
Publication Title
Medicine and Science in Sports and Exercise
Publisher
Lippincott Williams and Wilkins
School
School of Medical and Health Sciences / Exercise Medicine Research Institute
RAS ID
29100
Grant Number
NHMRC Number : 534409
Abstract
Purpose Androgen deprivation therapy (ADT) in men with prostate cancer (PCA) is associated with an array of adverse effects, including reduced bone mineral density (BMD) predisposing patients to increased fracture risk. Our purpose was to examine the effects of targeted exercise modes on BMD in men with PCA undergoing ADT. Methods Between 2009 and 2012, 154 PCA patients 43-90 yr old on ADT were randomized to exercise targeting the musculoskeletal system (impact loading + resistance training [ImpRes], n = 57) supervised for 12 months, cardiovascular and muscular systems (aerobic + resistance training, n = 50) supervised for 6 months followed by a 6-month home-based program, or delayed aerobic exercise (DelAer, n = 47) received exercise information for 6 months followed by 6 months of supervised aerobic exercise (stationary cycling). End points were lumbar spine, hip and whole-body BMD measured by dual-energy x-ray absorptiometry with secondary end points of lean and fat mass, appendicular skeletal muscle mass, and neuromuscular strength. ANOVA was used to compare the exercise groups with DelAer at 6 and 12 months. Results There was a between-group difference in BMD for ImpRes and DelAer at the spine (6 months, P = 0.039; 12 months, P = 0.035) and femoral neck (6 months, P = 0.050), with decline attenuated in ImpRes (-1.0% vs -2.0%). Compared with DelAer, ImpRes increased appendicular skeletal muscle at 6 months (0.3 kg, P = 0.045) and improved muscle strength at 6 and 12 months (P ≤ 0.012) by 9%-34%. A limitation was inclusion of well-functioning patients. Conclusion Combined impact loading and resistance exercise attenuates bone loss at the spine and enhances overall musculoskeletal function in PCA patients undergoing ADT. © 2018 by the American College of Sports Medicine.
DOI
10.1249/MSS.0000000000001831
Access Rights
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Comments
Newton, R. U., Galvão, D. A., Spry, N., Joseph, D., Chambers, S. K., Gardiner, R. A., . . . Taaffe, D. R. (2019). Exercise mode specificity for preserving spine and hip bone mineral density in prostate cancer patients. Medicine and Science in Sports and Exercise, 51(4), 607-614. Available here.