The potential of N-glycosylation profiles as biomarkers for monitoring the progression of Type II diabetes mellitus towards diabetic kidney disease
Abstract
Background: On a global scale, type II diabetes mellitus (T2DM) remain a major health problem and it is the driver for chronic kidney disease (CKD). Despite this association, we still do not have sufficient biomarkers to anticipate better outcomes. N-glycosylation profiles are robust biomarkers and can be used for early monitoring of the progression of T2DM towards CKD. Methods: In this cross-sectional study, we recruited 241 T2DM patients from January to May 2016. Demographic and anthropometric data were collected, following which fasting blood samples were collected for clinical analyses. Renal function decline was determined by estimation of glomerular filtration rate (eGFR) and N-glycosylation profiles were analysed by Ultra-performance liquid chromatography (UPLC). Results: The prevalence of undiagnosed CKD was 31.53%. Compared to men, women had a statistically significantly higher HbA1c (p = 0.031), TG (p = 0.015), HDL-c (p < 0.0001), creatinine (
Document Type
Journal Article
Date of Publication
12-1-2018
ISSN
2251-6581
Volume
17
Issue
2
PubMed ID
30918859
Publication Title
Journal of Diabetes & Metabolic Disorders
Publisher
Springer Nature
School
School of Medical and Health Sciences
RAS ID
27765
Copyright
subscription content
First Page
233
Last Page
246
Comments
Adua, E., Anto, E. O., Roberts, P., Kantanka, O. S., Aboagye, E., & Wang, W. (2018). The potential of N-glycosylation profiles as biomarkers for monitoring the progression of Type II diabetes mellitus towards diabetic kidney disease. Journal of Diabetes & Metabolic Disorders, 17(2), 233-246. Available here