Title

The potential of N-glycosylation profiles as biomarkers for monitoring the progression of Type II diabetes mellitus towards diabetic kidney disease

Document Type

Journal Article

Publication Title

Journal of Diabetes & Metabolic Disorders

ISSN

2251-6581

Volume

17

Issue

2

First Page

233

Last Page

246

PubMed ID

30918859

Publisher

Springer Nature

School

School of Medical and Health Sciences

RAS ID

27765

Comments

Originally published as: Adua, E., Anto, E. O., Roberts, P., Kantanka, O. S., Aboagye, E., & Wang, W. (2018). The potential of N-glycosylation profiles as biomarkers for monitoring the progression of Type II diabetes mellitus towards diabetic kidney disease. Journal of Diabetes & Metabolic Disorders, 17(2), 233-246. Original publication available here

Abstract

Background: On a global scale, type II diabetes mellitus (T2DM) remain a major health problem and it is the driver for chronic kidney disease (CKD). Despite this association, we still do not have sufficient biomarkers to anticipate better outcomes. N-glycosylation profiles are robust biomarkers and can be used for early monitoring of the progression of T2DM towards CKD. Methods: In this cross-sectional study, we recruited 241 T2DM patients from January to May 2016. Demographic and anthropometric data were collected, following which fasting blood samples were collected for clinical analyses. Renal function decline was determined by estimation of glomerular filtration rate (eGFR) and N-glycosylation profiles were analysed by Ultra-performance liquid chromatography (UPLC). Results: The prevalence of undiagnosed CKD was 31.53%. Compared to men, women had a statistically significantly higher HbA1c (p = 0.031), TG (p = 0.015), HDL-c (p < 0.0001), creatinine (

DOI

10.1007/s40200-018-0365-3

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