The impact of antimicrobial resistance on induction, transmission and treatment of Clostridium difficile infection

Document Type

Journal Article

Publication Title

Microbiology Australia

Publisher

CSIRO

School

School of Medical and Health Sciences

RAS ID

30243

Comments

Hong, S., Knight, D. R., & Riley, T. V. (2019). The impact of antimicrobial resistance on induction, transmission and treatment of Clostridium difficile infection. Microbiology Australia, 40(2), 77-81. Available here

Abstract

Clostridium difficile infection (CDI) of the gastrointestinal (GI) tract is a potentially life-threatening disease that has surpassed multi-drug-resistant Staphylococcus aureus as the commonest antimicrobial-resistant organism associated with healthcare. This obligate anaerobic spore-forming Gram-positive bacillus colonises the GI tract and its numbers increase after disruption of the commensal GI microbiota often induced by exposure to antimicrobial agents. Paradoxically, the disease that may follow its outgrowth necessitates further antimicrobial treatment. Already a major challenge to infection prevention and control strategies, there are indications that C. difficile is developing further resistance to currently used antimicrobial agents.

DOI

10.1071/MA19022

Access Rights

free_to_read

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