Autophagy promotes memory formation
Abstract
Autophagy is traditionally known to be a stress response and a quality control mechanism for protecting cells from injury and disease. In addition to its housekeeping functions, autophagy also has specialized functions including regulation of synaptic activity and neurotransmission. Decreased autophagy is commonly associated with aging; however, the functional importance of autophagy in regulating cognitive function and its decline during aging were previously not known. A recent study showed that the induction of hippocampal autophagy improves cognition by enhancing memory formation and reverses memory decline during aging. Here, we discuss the findings of that study and explore the scope of the physiological process of autophagy in the development of treatments for age-related cognitive decline and neurodegenerative diseases.
Document Type
Journal Article
Date of Publication
8-21-2019
ISSN
1948-7193
Volume
10
Issue
8
PubMed ID
31244056
Publication Title
ACS Chemical Neuroscience
Publisher
ACS Publications
School
The Centre of Excellence for Alzheimer’s Disease Research and Care / School of Medical and Health Sciences
RAS ID
30036
Copyright
subscription content
First Page
3337
Last Page
3339
Comments
Tripathi, T., Kalita, P., Martins, R., & Bharadwaj, P. (2019). Autophagy promotes memory formation. ACS Chemical Neuroscience, 10(8), 3337-3339. Available here