Responsiveness to resistance-based multimodal exercise among men with prostate cancer receiving Androgen Deprivation Therapy
Abstract
Background: Androgen deprivation therapy (ADT) in the management of prostate cancer (PCa) results in an array of adverse effects, and exercise is one strategy to counter treatment-related musculoskeletal toxicities. This study assessed the prevalence of exercise responsiveness in men with PCa undergoing ADT in terms of body composition, muscle strength, and physical function.
Methods: Prospective analyses were performed in 152 men (aged 43–90 years) with PCa receiving ADT who were engaged in resistance exercise combined with aerobic or impact training for 3 to 6 months. Whole-body lean mass and fat mass (FM), trunk FM, and appendicular skeletal muscle were assessed with dual x-ray absorptiometry; upper and lower body muscle strength were assessed with the one-repetition maximum; and physical function was assessed with a battery of tests (6-m usual, fast, and backward walk; 400-m walk; repeated chair rise; stair climb).
Results: Significant improvements were seen (PP
Conclusions: Despite considerable heterogeneity, most men with PCa receiving ADT responded to resistance-based multimodal exercise, and therefore our findings indicate that this form of exercise can be confidently prescribed to produce beneficial effects during active treatment.
Document Type
Journal Article
ISSN
1540-1413
Volume
17
Issue
10
PubMed ID
31590154
School
School of Medical and Health Sciences
RAS ID
30001
Copyright
subscription content
Publisher
National Comprehensive Cancer Network
Comments
Taaffe, D. R., Newton, R. U., Spry, N., Joseph, D. J., & Galvão, D. A. (2019). Responsiveness to resistance-based multimodal exercise among men with prostate cancer receiving Androgen Deprivation Therapy. Journal of the National Comprehensive Cancer Network, 17(10), 1211-1220.
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