Title

Responsiveness to resistance-based multimodal exercise among men with prostate cancer receiving Androgen Deprivation Therapy

Document Type

Journal Article

Publication Title

Journal of the National Comprehensive Cancer Network

ISSN

1540-1413

Volume

17

Issue

10

First Page

1211

Last Page

1220

PubMed ID

31590154

Publisher

National Comprehensive Cancer Network

School

School of Medical and Health Sciences

RAS ID

30001

Comments

Originally published as: Taaffe, D. R., Newton, R. U., Spry, N., Joseph, D. J., & Galvão, D. A. (2019). Responsiveness to resistance-based multimodal exercise among men with prostate cancer receiving Androgen Deprivation Therapy. Journal of the National Comprehensive Cancer Network, 17(10), 1211-1220.

Original article available here.

Abstract

Background: Androgen deprivation therapy (ADT) in the management of prostate cancer (PCa) results in an array of adverse effects, and exercise is one strategy to counter treatment-related musculoskeletal toxicities. This study assessed the prevalence of exercise responsiveness in men with PCa undergoing ADT in terms of body composition, muscle strength, and physical function.

Methods: Prospective analyses were performed in 152 men (aged 43–90 years) with PCa receiving ADT who were engaged in resistance exercise combined with aerobic or impact training for 3 to 6 months. Whole-body lean mass and fat mass (FM), trunk FM, and appendicular skeletal muscle were assessed with dual x-ray absorptiometry; upper and lower body muscle strength were assessed with the one-repetition maximum; and physical function was assessed with a battery of tests (6-m usual, fast, and backward walk; 400-m walk; repeated chair rise; stair climb).

Results: Significant improvements were seen (PP

Conclusions: Despite considerable heterogeneity, most men with PCa receiving ADT responded to resistance-based multimodal exercise, and therefore our findings indicate that this form of exercise can be confidently prescribed to produce beneficial effects during active treatment.

DOI

10.6004/jnccn.2019.7311

Access Rights

free_to_read

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