Document Type
Journal Article
Publication Title
Molecular Genetics and Genomic Medicine
Publisher
Wiley
School
School of Medical and Health Sciences
RAS ID
31060
Abstract
Background: Two genome-wide association studies in European and Japanese populations reported on new loci for diabetic kidney disease (DKD), including FTO. In this study, we have replicated these investigations on a cohort of 410 Type 2 diabetes mellitus (T2DM) patients of Arab origin from the United Arab Emirates (UAE). Methods and Results: The cohort included 145 diabetic patients diagnosed with DKD and 265 diabetics free of the disease. In general, we were able to confirm the association between the FTO locus and DKD, as reported in the Japanese population. Specifically, there were significant associations with two single nucleotide polymorphisms (SNPs), namely rs1421086 (p =.013, OR = 1.52 depending on allele G, 95% CI: 1.09–2.11) and rs17817449 (p =.0088, OR = 1.55 depending on allele C, 95% CI: 1.12–2.14) of the FTO locus. Both SNPs were in linkage disequilibrium with rs56094641, also as reported in the Japanese population. While the alleles of both SNPs, which increase the risk of DKD, were associated with higher Body Mass Index (BMI), their associations with DKD were independent of the BMI effects. Conclusions: This study confirms that FTO is a multiethnic locus for DKD which is independent from any influence of BMI and/or obesity.
DOI
10.1002/mgg3.985
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Comments
Osman, W. M., Jelinek, H. F., Tay, G. K., Hassan, M. H., Almahmeed, W., Khandoker, A. H., ... Alsafar, H. S. (2019). Genetics of diabetic kidney disease: A follow‐up study in the Arab population of the United Arab Emirates. Molecular Genetics and Genomic Medicine, 7(12), Article e985. Available here