Association of plasma C‐reactive protein with ischaemic stroke: a Mendelian randomization study
Authors
X. Zhang
A. Wang
J. Zhang
M. Singh, Edith Cowan University
D. Liu
Y. Zuo
L. Wu
M. Song
Wei Wang, Edith Cowan UniversityFollow
V. Feigin
Y. Wang
D. Zheng
Document Type
Journal Article
Publication Title
European journal of neurology
Publisher
Wiley
School
School of Medical and Health Sciences
RAS ID
30234
Grant Number
NHMRC Number : 1112767
Abstract
Background and purpose
Elevated C‐reactive protein (CRP) is associated with an increased risk of ischaemic stroke (IS). However, the causality of this association is uncertain. The aim is to investigate whether genetically raised plasma CRP concentration levels are associated with IS on the basis of the Mendelian randomization method.
Methods
Based on the National Center for Biotechnology Information single nucleotide polymorphism (SNP) database, the Chinese online genetic database as well as previously published studies, four CRP‐associated SNP alleles (rs1130864, rs1205, rs876537 and rs3093059) with minor allele frequency ≥0.15 were selected and the concentration levels of CRP were measured in 378 first‐ever IS patients and 613 healthy controls.
Results
Three SNPs were chosen and used as instrumental variables. The adjusted odds ratios (ORs) [95% confidence interval (95% CI)] of IS per addition of the modelled allele were 1.07 (0.79–1.45) for rs876537, 0.99 (0.73–1.35) for rs1205 and 1.08 (0.71–1.65) for rs3093059. The OR (95% CI) of IS for plasma CRP ≥2.0 mg/l was 2.19 (1.06–4.53) compared with
Conclusions
This Mendelian randomization study provides no clear support that elevated CRP concentration is causally associated with the risk of IS.
DOI
10.1111/ene.14113
Access Rights
subscription content
Comments
Zhang, X., Wang, A., Zhang, J., Singh, M., Liu, D., Zuo, Y., ... & Wang, Y. (2020). Association of plasma C‐reactive protein with ischaemic stroke: a Mendelian randomization study. European journal of neurology. 27(3) 565-571.
https://doi.org/10.1111/ene.14113